Because of a lack of fiber in their daily diet, women in particular suffer from digestive irregularity. “Regular Girl” is a synbiotic blend of two key ingredients — Taiyo’s clinically proven prebiotic Sunfiber® and functional probiotics such as Bifidus lactis — for a healthy gut in one easy-to-take product. The neutral powder contains only natural ingredients, is non-GMO verified, gluten-free and vegetarian. First launched and marketed in the USA two years ago, Regular Girl is now available in the EMEA (Europe, Middle East and Africa).

 As the brand name and the packaging design implies, Regular Girl has been created for health conscious women. Although the multiple benefits of fibers and probiotics for a healthy gut are well known, time is often too tight to follow a healthy and balanced diet. Formulated by a female nutritionist, each single-serving of Regular Girl combines 5 g of Taiyo’s clinically proven prebiotic Sunfiber® and 8 billion active probiotics. As such, it’s a perfect source of soluble prebiotic fiber to promote a healthy intestinal microflora. The fermentation rate is neither too fast nor too slow, which means no painful gas, diarrhea, bloating or cramping. Furthermore Regular Girl helps to prevent constipation and maintain intestinal and bowel regularity for overall well-being.

As a non-irritant ingredient, it is very compatible and even suitable for people who suffer from irritable bowel syndrome. The combination of Sunfiber® and active probiotics might also play a role in managing and maintaining a healthy body weight, healthy blood fat levels and healthy blood sugar levels: it indices a comfortably full and satiated feeling, and a natural desire to eat less.

The single-serving sticks of Regular Girl simplify daily fiber and probiotic consumption, even on-the-go, just by adding the powder to a meal or drink. Thanks to its high solubility, it mixes perfectly with hot and cold beverages, smoothies and cereals without impacting taste or texture.

“We are very proud that Sunfiber® is a major part of the innovative Regular Girl product. Our prebiotic ingredient is ideally suited to ensuring sufficient dietary fiber intake without negative side-effects such as bloating,” says Dr Stefan Siebrecht, Managing Director of Taiyo GmbH. “We are confident that many women will benefit from this innovative product — and maybe also recommend it to their family, as Regular Girl promotes digestive health for everybody.”

June 9, 2017 – [Ankeny, IA] Embria Health Sciences, LLC, manufacturer of EpiCor® fermentate, has partnered with Nutritional Division of LEHVOSS UK – Gee Lawson to distribute its flagship ingredient to key countries in Western Europe including United Kingdom, Italy, France, Germany, Spain, the Scandinavia and Benelux regions.

“LEHVOSS’s commitment to nutrition was made with the acquisition of Gee Lawson as one of the leading distributors of high quality research-based ingredients in Europe. Adding EpiCor® to our portfolio gives us the opportunity to provide our customers with an immune and digestive health solution which can be applied many sectors, underpinned by science and something not currently enjoyed by many countries,” stated Jonathan Shorts, Head of LifeSciences LEHVOSS UK Ltd/Gee Lawson.

EpiCor® is a natural, whole food fermentation ingredient made from a proprietary process. EpiCor’s metabolite-rich composition includes proteins, fibers, polyphenols, vitamins, amino acids, polysaccharides (including beta glucans) and many other beneficial bioactive metabolite compounds that work together to support a strong immune and digestive system.
Eight human clinical studies covering hundreds of subjects show EpiCor® supports wellness by strengthening the immune system and supporting gastro-intestinal health. As a complex ingredient, EpiCor® has many of documented modes of action, including increasing sIgA antibodies, activating certain white blood cell activity (Natural Killer cells), and boosting antioxidant power..

“With our continued success in USA and other countries throughout the world, we are excited about this opportunity to expand into Western Europe, collectively among the largest dietary supplement markets in the world,” says Jeff Cannon, President and CEO of Diamond V, the parent company of Embria Health Sciences. “Embria chooses partners carefully. We are excited about Gee Lawson’s ability to grow demand for EpiCor® in this very important region of the world that demands value, science and quality.”

About EpiCor®
EpiCor®, manufactured by Embria Health Sciences®, is a safe and natural whole food fermentation ingredient that helps support the immune and digestive systems. It is a complex, nutrient-rich ingredient comprised of immune-supporting metabolites as well as proteins, vitamins, minerals, amino acids, polyphenols and beta glucans. Taken daily, EpiCor has been shown to be a safe and effective way to he

A NEW HUMAN CLINICAL STUDY from The Ohio State University Wexner Medical Center, published in PubMed listed Journal of Medicinal Food, shows that oral supplementation with Natreon’s PrimaVie® Purified Shilajit can significantly up-regulate the genes responsible for synthesis of collagen and other extracellular matrix proteins resulting in adaptation of the skeletal muscle mechanotrasduction properties, elasticity, repair and regeneration.

Natreon’s PrimaVie®, a high quality, purified and standardized extract of Shilajit, significantly up-regulated the genes responsible for collagen synthesis according to a human clinical study just published in the Journal of Medicinal Food. PrimaVie®, a GRAS affirmed and patented ingredient, is comprised of mainly fulvic acids and DBPs (dibenzo-α-pyrones). Fulvic acid independently stimulates mitochondrial energy metabolism, protects mitochondrial membranes from oxidative damage, and helps channel electron-rich DBPs into the mitochondria to support the electron transfer chain. Several clinical studies have shown that PrimaVie® can boost mitochondrial energy, improve exercise performance, and increase testosterone levels. It was shown to increase ATP synthesis and protect Coenzyme Q10 from degradation by oxidative free radicals in the mitochondria. This most recent collagen expression study suggests PrimaVie®’s role in healthy aging.

In this open label longitudinal study, sixteen overweight/Class I obese Americans (both genders) were followed for 12 weeks to determine the effects of oral supplementation of PrimaVie® and exercise training on human skeletal muscle adaptation. This particular cohort was selected for the study because physiological muscle performance is often compromised in this group of subjects. The subjects received 250 mg of PrimaVie® twice daily for 8 weeks followed by an additional 4 weeks of supplementation with exercise. To determine the changes in mRNA expression profile in response to PrimaVie® supplementation and exercise, skeletal muscle biopsies of the thigh muscle were done followed by RNA extraction, target labeling, and GeneChip data analysis. The genes that were expressed highly in skeletal muscle samples after 8 weeks of supplementation compared to baseline included tenaxcin XB (TNXB), decorin (DCN), myoferlin (MYOF), collagen (COL) (type I, II, III, V, VI, XIV), elastin (ELN), fibrillin 1(FBN1), and fibronectin 1 (FN1). Several collagen related genes, including COL1A1, COL1A2, and COL3A1 were increased by 4.61 (p = .0149), 5.13 (p = .0076), and 5.18 fold (p = .0086), respectively. To validate the genes identified using microarray analysis, RT-PCR was performed and the up-regulated genes mentioned above were re-examined. Consistent with microarray results, significant up-regulation of collagen and other ECM-associated genes was noted in the muscle samples (some up to 1500 fold) in the muscle samples following 8 weeks of oral supplementation of PrimaVie® compared with the baseline visit. Interestingly, an additional 4 weeks of PrimaVie® supplementation with exercise further induced the expression of the microarray identified genes. In addition, PrimaVie® supplementation was well tolerated without any changes in blood glucose levels and lipid profile. Although additional studies will follow to confirm the effects of oral supplementation of PrimaVie®, the increase in collagen expression in this study suggests the potential role of PrimaVie® Purified Shilajit in healthy aging.

The full study is available at: http://online.liebertpub.com/doi/pdf/10.1089/jmf.2016.0010

Gnosis, the One-Carbon Metabolism dedicated company, supports the International Conference ICHOCM 2017

New highlights on folate MTHFR polymorphism from ICHOCM 2017. Really interesting scientific data have been presented at the just closed 11^th  International Conference on Homocysteine and One-Carbon Metabolism, held in Aarhus, Denmark last week. As a part of a wider plan, Gnosis is proud to have been official sponsor of the event.

During the four-day convention, many internationally experts gave lectures about the One-Carbon Metabolism (often referred as methylation cycle) and its link with Folate, SAMe and Glutathione, in order to share and learn the latest scientific knowledge and experiences and enhance our facilities.

The scientific program full of speeches and researches by the foremost scientists from all around the world brings you to the topic of the conferences that is “Taking science to the next level – challenging paradigms and conventions”.

Among others, two special focuses have been devoted to:

1) the role of methyltetrahydrofolate reductase polymorphism (MTHFR) and its incidence in health and disease, including cardiovascular disease, neurodegenerative disease (Alzheimer’s disease and dementia, Parkinson’s disease), birth defects, and comorbidities associated with obesity;

2) challenges to evaluating evidence of risks from high intakes of folic acid by supplementation.

For a company like Gnosis, pioneer in the development of vital components involved in  methylation cycle and One-Carbon Metabolism network, this conference has been the timely occasion to explore, characterize and strengthen knowledge about the role of Quatrefolic®, the biologically active form of folate, that support the cycle independently of genetic variation of MTHFR enzyme, and free from risk of accumulation typical of folic acid administration.

MTHFR enzyme catalyzes the irreversible conversion of 5,10-methylenetetrahydrofolate to the active form of folate, the 5-methyltetrahydrofolate (5-MTHF) and is considered the key in the One-Carbon Metabolism pathway. Deficiencies in production or function due to polymorphism are implicated with elevated homocysteine concentrations and consequently in chronic disease states.

MTHFR deficiency increases the risk of stroke, reports the work presented by Dr. Nafisa M. Jadavji et al. Stroke is a leading cause of disability and death world-wide. She has investigated the mechanism through which the MTHFR polymorphism may have a role using in vitro and in vivo tools. Study results point out that individuals with the homozygous polymorphism of MTHFR (TT genotype) have elevated homocysteine concentrations and that MTHFR deficiency increases vulnerability to stroke and leads to more severe impairment after stroke through increased apoptosis and oxidative stress.

Regarding folic acid scientific research is increasingly interested on the potential for adverse effects of high intakes of folic acid. Interesting results have been presented by Dr. Emily C. McGowan et al. on the hypothesis that the increased food allergy prevalence observed in recent years may involve changes in our nutrition, including increased exposure to folic acid through fortification and supplement use.

Moreover new highlights have been presented about the connection between One-Carbon’s perturbations and the deficiency of specific nutrients vital for life such as S-adenosylmethionine/SAMe, and glutathione, both present in Gnosis’ pipeline like Adonat® and Emothion™.

Schwelm, May 2017 – During Vitafoods, Taiyo presented new varieties of its all-natu­ral, soluble dietary fiber Sunfiber®, which can now also be used as a sweetener. At the same time, the company showed solutions that contribute to balanced blood sugar levels. The sugar-like, mild taste profile of Sweet-Sunfiber® and Sunfiber®-Matcha honey, as well as their special technological properties, give end products a pleasant sweetness and texture. In addition, consumers benefit from the health-boosting advantages of the prebiotic fiber.

The Sweet-Sunfiber® compound combines Sunfiber® with isomalto-oligosaccharide, a natural component of honey or sugar cane, which provides foods with a sugar-like sweetness profile. Due to its non-cariogenic properties, isomalto-oligosaccharide is tooth-friendly and convinces with a low glycemic index. It gets metabolized more slowly than normal sugar, which is why blood glucose levels rises less sharply too. This healthy alternative to conventional sugars helps to reduce blood sugar spikes and decrease the amount of insulin released in the body. Especially important for diabetic patients, a lower insulin reaction is also a prerequisite for effective weight management.

In addition, the fiber in the functional compound has various prebiotic properties, promoting the growth of short-chain fatty acids in the colon, which, in the long-term helps to prevent nutrition-related diseases.

The Sunfiber® range also offers optimized technological benefits. The ingredients are highly water soluble, stable at different pH levels and temperatures, and can therefore be used for a variety of applications, such as dairy and bakery products, meats and sausages, beverages, ice-creams and confectioneries.

The bio-certified Sunfiber®-Matcha Honey convinces with an exciting mixture of sweetness and a refreshingly herbal green tea flavor. In addition, it is a healthy alternative to saccharose; Matcha is known for its antioxidant activity, whereas honey has antibacterial properties.

Dr Stefan Siebrecht, Managing Director of Taiyo GmbH, comments: “Whether for health reasons or as a part of a diet, more and more consumers are reducing their sugar consumption. As a result, the demand for reduced sugar products or foods with alternative sweetening solutions is increasing. Taiyo recognizes these consumer demands and now offers sweet Sunfiber® varieties, functional ingredients that have a balanced sweet profile. At the same time, they provide well-tolerated dietary fibers and can be used in many applications.”

The Sunfiber® portfolio qualifies as an organic material, is non-GMO and a 100% gluten-free product. It is Kosher and Halal certified and perfectly suitable for vegetarians and vegans.

ACTIV’INSIDE is very proud to be winner of the NutraIngredients Awards 2017 with Memophenol^TM, selected among several dozens of products as “Ingredient of the Year”, in the Healthy Ageing category. This award recognizes “true innovation and cutting edge research in healthy foods, supplements and nutrition”.

More than just an award, this “Ingredient of the Year” prize reflects the uniqueness of Memophenol^TM, an innovative formulation clinically proven to improve cognitive functions, resulting from a large International research program and based on a full scientific, demonstrated, published and patented action.

Activ’Inside won the battle against several dozens of entries, according to a team of expert judges. Each participant has submitted a file per innovative product by January 2017.

The selection was made according to 6 criteria:

• Science – Is the nutrient backed by peer-reviewed safety and efficacy research?
• Innovation– Demonstrate the nutrient’s genuinely novel position in the market. How is this achieved?
• Commerciality– Demonstrate the nutrient’s commercial success to date and formulation/application use and future potential. What problem does it solve?
• Marketing– Demonstrate how the nutrient is being marketed and to which demographic(s)? Are there any trends inspiring your nutrient?
• Markets/channels – In which markets is it present and via which channels did it get there?
• Nutra pride – Is this a contribution the nutrition world can be proud of? Why?

Memophenol^TM ingredient has excelled in the “Ingredient of the Year – Healthy Ageing” category. Selected as finalist and presented to the jury by the Wednesday 10^th May, in Geneva, during the second day of Vitafoods Europe 2017, Memophenol^TM by Activ’Inside was announced winner during the awards ceremony by Wednesday 10^th May evening.

“This award is the reflect of Memophenol^TM uniqueness. The committed R&D approaches, with 8 pre-clinical scientific studies performed, combined with the clinically proven effectiveness on learning and memory, are assets and factors of differentiation for a singular Healthy Ageing Ingredient” says Benoit LEMAIRE, CEO of ACTIV’INSIDE.

Kaneka’s Ubiquinol and Glavonoid with scientifically proven functions for use in health-improving and sports supplements

Brussels (Belgium), May 2017 – At this year’s Vitafoods, Kaneka Pharma Europe presented Kaneka Ubiquinol™, the most active form of coenzyme Q10. Used as a nutritional supplement, the ingredient helps to prevent several diseases associated with aging. Thanks to its confirmed benefits on muscle performance and recovery, a number of professional athletes have already adopted Kaneka Ubiquinol™ as part of their training schedule. The company also focused on the visceral fat-reducing and Novel Food-approved licorice root extract Glavonoid™, which has great promise for sports and fitness applications.

Besides Ubiquinol’s essential role in energy production, it is the only endogenously synthesised lipid-soluble antioxidant and therefore protects cell membranes from free radical damage. Its high bioavailability and bio accessibility enables Ubiquinol to be taken up by the body more quickly and efficiently than oxidized coenzyme Q10. Ubiquinol is scientifically proven to counteract several age-related ailments. Recently, in one of the largest ever studies, involving 1,911 subjects, Dr Frank Döring was able to demonstrate the function of Ubiquinol in gene expression: “People with low levels of Ubiquinol have higher levels of BNP and CRP, which are essential molecules of inflammatory processes and play an important role as risk factors for heart disease.” Ubiquinol is also vital for improving recovery in healthy individuals. The latest products target active “Best Agers” who want to stay healthy, as well as athletes who are keen to optimise their immune defences and muscular capabilities. Several European sports professionals have already started to use Kaneka Ubiquinol™, and its activity for athletes is backed by various scientific studies. Having thus far been mainly available in capsule form, Kaneka has now developed a stabilized Ubiquinol powder for use in powdered and liquid applications.

Furthermore, Kaneka showcased the Novel Food-approved plant extract Glavonoid™, which was originally developed to prevent metabolic syndrome. Derived from licorice root (Glycyrrhiza glabra L.), Glavonoid™ has been proven to be completely safe and is approved by the European authorities with Novel Food ingredient status. An advanced, patented extraction process ensures that the ingredient does not contain any glycyrrhizinic acid, making it free from the unwanted side-effects of licorice. Glavonoid™ is able to increase the body’s own fat burning ability, while at the same time decreasing fat synthesis by down-regulating genes that are involved in fatty acid development. Since 2015, Glavonoid™ has been approved for extended use in foods for medical purposes and energy-restricted diets for weight reduction.

A recent randomized, double-blind, placebo-controlled study conducted in 2016 verified that Glavonoid™ can also increase skeletal muscle mass in humans in combination with exercise. During the study, male American Football athletes ingested 300 mg Glavonoid™ per day over 8 weeks of training. Ultrasound imaging analysis revealed that the muscle thickness of the anterior thighs and anterior brachial regions in the Glavonoid™ group were both significantly increased by 2.5% at week 8 in comparison to baseline. There was no such increase in the placebo group. Abdominal muscle thickness increased in both groups, but the increase was 1.8 times greater in the Glavonoid group than in the placebo group (p<0.05). It can therefore be seen that Glavonoid™ is ideal for inclusion in products aimed at the sports and fitness market.

The combination of natural-derived vitamin K2 with octacosanol (the main constituent of policosanol) could contribute to lowering levels of cholesterol, triglycerides, LDL-cholesterol, and its combination with a statin can achieve the target value of LDL- and HDL-cholesterol, say a new study published by Jovanovic et al in International Journal of Pharmaceutical Science and Invention.

The study was conducted as a prospective clinical study and included a total of 6595 subjects. The study group included 4031 subjects (1785 males and 2246 females) who were taking a combination of natural Vitamin K2/MK7 from Bacillus subtilis Natto 45μg , vitaMK7® (by Gnosis, Italy) with 20 mg of Octacosanol under the brand name of ARTEROprotect® (by Abela Pharm, Serbia) while the control group compromised 2564 subjects (1135 males and 1428 females) who were not taking it.

The study was conducted by 76 doctors – general practitioners, specialists in internal medicine and cardiology – in in primary health centers throughout the Republic of Serbia, in accordance with the principles of good clinical practice and the Declaration of Helsinki.

Based on the results, it can be said that dietary supplement ARTEROprotect® used alone can contribute to lowering levels of blood fat, and in combination with a statin it can achieve the target value of HDL-cholesterol.

Vitamin K2-MK7 used for ARTEROprotect® is obtained by a patented biofermentation process (property of Gnosis Spa) which ensures a high yield of the natural vitamin K2. VitaMK7® offers the highest content of all-trans MK7, free from solvents and chemicals and in compliance with USP Pharmacopeia. The high purity and stability profile allow the powder to be used as is, without applying coating or chemical microencapsulation.

A polyphenol-rich formulation may improve physical performance during highintensity
exercise.
Fytexia launched 6 months ago in the US its new range of sports nutrition ingredients and
will present them for the first time in Europe at Vitafoods 2017. All supported by clinical
proves of efficacy, the French company announces today the publication of a new
clinical study in the under-review journal Nutrients demonstrating the benefits of
PerfLoad®, its formulation targeting sports performance.
 
“Supplementation with a Polyphenol-Rich Extract, PerfLoad®, Improves Physical
Performance during High-Intensity Exercise: A Randomized, Double Blind, Crossover Trial”
Julien Cases, Cindy Romain, Cristian Marín-Pagán Prost-Camus et al.
Published online, April, 24th, 2017 (http://www.mdpi.com/2072-6643/9/4/421/htm)
Expert in the science of polyphenols, the aim of Fytexia is to bring out the vast – and
mostly unexploited – potential of these natural bioactives for the optimization of physical
activity. With the market evolving into the mainstream, brands willing to sustainably
occupy the new space must create products suited for wider exposure. In other words,
formulas must be perfectly safe, supported by strong human evidence, and made of
natural, non-GMO ingredients that people can recognize and trust.
 
PerfLoad® is a flavonoid-rich ingredient formulated from grape, pomegranate and green
tea extracts. The natural composition has been designed to target heavier performance
using polyphenol strength to improve peak power and total anaerobic work capacity.
A randomized, placebo-controlled, crossover study, was conducted in the Research
Center of High Performance Sport of the University of Murcia (Spain) to evaluate whether
PerfLoad® could improve physical performance during high-intensity exercise, in
anaerobic condition, while sustaining physiological and biochemical processes of 15
recreationally-active sportsmen.
The Wingate test was used to assess maximum anaerobic power during a high intensity
exercise on a cycle ergometer.
 
Supplementation with PerfLoad® was correlated with a significant increase in the total
anaerobic work capacity by 5% which represents an increase of 876 joules developed in
30 seconds. 900 mg of PerfLoad®, taken pre-workout, was proven to provide explosive
power from the very start of the exercise and the maximal peak power output was
significantly increased by 3.7% without inducing higher fatigue or higher heart rate at
V02max. Besides, blood markers showed that oxidative homeostasis was stabilized in
supplemented subjects.
 
As pre-workout supplementation has become a significant nutritional approach in recent
years, such results demonstrated that the water-soluble ingredient, PerfLoad®, can be a
natural and efficient solution helping athletes to improve their physical performance
while balancing their metabolism and reducing exercise-induced oxidative stress.

According to Gnosis, vitaMK7®, vitamin K2 as MK7, is the only natural-derived vitamin K2 from Bacillus subtilis natto, produced by Gnosis proprietary patented biofermentation process, chemicals and solvents free. vitaMK7® is the highest pure natural vitamin K2 as MK7 and the most stable form in the market.

https://www.youtube.com/watch?v=71DYe7BHAgI&feature=em-subs_digest