LONGVIDA® primed for Sports Nutrition: Batch verified for Sports banned Substances + Vascular endothelial Health Study

MAY 2017 –Longvida® Optimized Curcumin passed rigorous testing for banned substances for professional athletes. The batch tested below detection limits for a screen of over 200 compounds. This batch-specific certification, Certified for Sports by Korva Labs, is announced and available to customers for purchase moving forward. Verdure is excited to expand the pipeline of quality and assurance parameters with another available certification.

Representatives will be available to answer your questions in person at Vitafoods booth H2O where they are excited to talk about the independent NIH funded study in Aging; Curcumin

[Longvida®] improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress1. This clinical trial examined supplementation of Longvida® in regards to improvements in resistance and conduit artery endothelial function and large elastic artery stiffness. “We are excited to have an additional study showing Longvida’s benefits that further backs the safety data already available on Longvida® Optimized Curcumin,” explained Kristen Marshall, Marketing Coordinator, Verdure Sciences.

Nitric oxide bioavailability is important for healthy joints as nitric oxide is known to be a key mediator of vasodilation, inflammation, and pain perception. After 12 weeks of supplementation, forearm blood flow increased 37% for those taking Longvida® (P=0.03), whereas no change was seen in the placebo group (P=0.2). Furthermore, the scientists go on to say that, “specifically, 12 weeks of curcumin supplementation increased nitric-oxide dependent dilation (P=0.03), whereas no change was observed in the placebo group (P=0.7).” These results were confirmation of similar results seen in the pilot trial conducted prior to this clinical. Kristen Marshall, Marketing Coordinator, Verdure Sciences®, said that she was pleased to see additional support of Longvida’s efficacious ability to promote healthy aging. Twelve weeks of Longvida® also reduced oxidative stress suppression of endothelium-dependent dilation, again with no change seen in placebo.1

The researchers then summarize their findings saying that 12 weeks of Longvida, at 2000mg/day, was found to be safe and well tolerated. It improved resistance and conduit artery endothelial function in healthy middle-aged and older adults, and improvements in endothelial function were mediated by an increase in nitric oxide bioavailability and a reduction in vascular oxidative stress. “Taken together, these data suggest that [Longvida®] may be a promising therapeutic option to improve age-related vascular endothelial function in middle-aged and older adults.”1

“Backed with studies by McFarlin et al for exercise recovery (400mg/day), Santos-Parker et al for vascular endothelial health (2000mg/day), and now available with validated batch specific certification as free of banned substances for athletes worldwide, it is no surprise to see increased interest in our Longvida® curcumin in finished products targeting sports nutrition and joint health for demographics of all ages,” said Marshall.

In 2016, Researchers with the University of North Texas examined Longvida® supplementation as therapy for exercise-induced muscle damage (EIMD) and delayed onset muscle soreness (DOMS) impact post training and activities of daily living (ADL). The study utilized an easily managed, once daily 400mg dose of Longvida, versus equivalent placebo, with EIMD from participation in a leg press exercise. This exercise design was chosen to ensure that inflammatory biomarkers presented were appropriately measured and not inflated due to impact to other joints and areas, as can often present in a downhill running model.2

The researchers’ findings, “support the use of oral curcumin supplementation [as Longvida® Optimized Curcumin] to reduce the symptoms of EIMD,” as key biomarkers indicated that supplementation with Longvida® showed statistically significant improvements in inflammatory cytokines (see heat map below).2

Further excitement for Verdure takes form of attendance at Vitafoods in Geneva where Longvida®, Pomella® and WokVel®, will be highlighted at stand H2O which is hosted by distributor Gee Lawson.†

References:

¹ Santos-Parker JR et al. Curcumin [Longvida®] supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress. Aging. 2017 Jan 3. Vol 9(No 1): 187-208.

² McFarlin BK et al. Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin [Longvida®]. BBS Clinical. 2016 Feb 18. 5: 72-78. DOI: 10.1016/j.bbacli.2016.02.003

 

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Kyowa to Discuss Benefits of Cognizin Citicoline at Vitafoods Europe in Geneva

Cognizin® Citicoline’s Breakthrough Benefits for Cognition and a Review of the Science.

Kyowa Hakko Europe and Kyowa Hakko Bio Italia will host a special seminar titled “Cognizin® Citicoline’s Breakthrough Benefits for Cognition and a Review of the Science” to discuss the benefits of citicoline for brain health at Vitafoods™ Europe on May 9 in Geneva, Switzerland.

The 30-minute session will be held May 9 at 11:05 a.m. GMT/UTC+2 in the Exhibitor Presentation Theatre at the Palexpo Convention Centre and will be presented by Karen E. Todd, Kyowa Hakko U.S.A. director of global brand marketing.

Attendees will learn why brain health is a global concern and how Cognizin® Citicoline is designed to provide the brain nutrition to stay sharp. Ms. Todd will outline the science behind Cognizin®, its patented fermentation technology and how the ingredient can be applied to a variety of health and nutrition products.

About Karen E. Todd

Karen E. Todd is a Registered Dietitian, Certified Strength and Conditioning Specialist and Health & Fitness Specialist with more than 25 years’ experience in exercise performance and nutritional product development and education. Currently, she is the Sr. Director of Global Brand Marketing for Kyowa Hakko U.S.A.

About Vitafoods Europe

Vitafoods Europe is the global nutraceutical event, featuring exhibitors from all over the world in four key market areas: ingredients & raw materials; branded finished products; contract manufacturing & private label; and services & equipment. The event offers a range of visitor attractions, including an industry-leading education programme.

Vitafoods Europe is part of Informa Exhibitions’ Global Health & Nutrition Network (GHNN), which brings together a portfolio of events, digital media and publishing for marketers, manufacturers and formulators of nutrition and dietary supplements, healthy foods/beverages and personal care products. GHNN’s events include Vitafoods Europe, Vitafoods Asia, SupplySide West and Ingredient Marketplace.

About Kyowa Hakko Europe and Kyowa Hakko Bio Italia

Kyowa Hakko Europe and Kyowa Hakko Bio Italia are the Central-North and South European sales office for Kyowa Hakko Bio Co. Ltd., an international health ingredients manufacturer and world leader in the development, manufacturing and marketing of pharmaceuticals, nutraceuticals and food products. For more information visit www.kyowa.eu or email at finechemicals@kyowa.it

About Kyowa Hakko USA

Kyowa Hakko USA is the North American sales office for Kyowa Hakko Bio Co. Ltd., an international health ingredients manufacturer and world leader in the development, manufacturing and marketing of pharmaceuticals, nutraceuticals and food products. Kyowa is the maker of branded ingredients including Cognizin® Citicoline, Pantesin® Pantethine, Setria® Glutathione, as well as Sustamine® L-Alanyl-L-Glutamine. For more information visit www.kyowa-usa.com

 

Kyowa Hakko Introduces Setria® Performance Blend

New York City, NY April 27, 2017 – Kyowa is pleased to announce the launch of Setria® Performance Blend. Setria® Performance Blend is a new, branded, patent-pending blend of Kyowa’s L-citrulline and Setria® glutathione. Studies have shown that this blend supports NO production, and sustains NO levels in the bloodstream twice as long as comparable doses of l-arginine or l-citrulline.

New research in resistance-trained males suggests that Setria® Performance Blend may help sustain NO levels which could lead to reduced fatigue and speed recovery.* Get the strength-training results you want with long lasting nitric oxide (NO) production.*

A combination of L-Citrulline (CIT) and Setria supplementation significantly increased NO levels in HUVECs.

 

One week of daily oral supplementation with 200 mg of Setria and 2 grams of L-Citrulline enhanced NO levels at 30 min. post-exercise.

Setria® Performance Blend

  1. Supports NO levels*
  2. Sustains NO levels for a long-lasting effect*
  3. Aids in vasodilation to fuel muscles*
References
  1. McKinley S, Andrew T, Morita M, Willoughby D. Combined L-Citrulline and Glutathione Supplementation Increases the Concentration of Markers Indicative of Nitric Oxide Synthesis. Journal of the International Society of Sports Nutrition. 2015, 12:27
https://jissn.biomedcentral.com/articles/10.1186/s12970-015-0086-7
*Setria® is a registered trademark and owner of Patent Application US 20150011463 A1 from KYOWA HAKKO BIO CO., LTD.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Mythocondro obtains GRAS Status by FDA

Gnosis S.p.A. announced that the US Food and Drug Administration (FDA) has positively finalized its determination that Mythocondro®, the Non-Animal Chondroitin Sulfate, has a granted GRAS Status (Generally Recognized as Safe) for the proposed uses as a food ingredient.

The GRAS Status was reached after the voluntary notification presented by Gnosis to FDA Center for Food Safety & Applied Nutrition, where the innovative vegetarian alternative of CS was subjected to a complete quality and safety testing supported by published clinical data. The overcome of animal-derived CS limits will result in an innovative new suite of fermentation-derived animal-free finished products whose quality, purity, reliability and functionality should be highly attractive to the global market.

Based on the information provided by Gnosis, as well as other information available to FDA, the agency concluded the evaluation with “no questions”.

With this new important achievement the US market opens its doors to Mythocondro®, also suitable for people with dietary restrictions related to religious and animal supply issues. Mythocondro® is under registration in several countries; in Europe the Novel Food Approval by EFSA is ongoing.

Mythocondro® is the first Non-Animal Chondroitin Sulfate (CS) obtained through a fermentation-based manufacturing process providing a reliable and reproducible source of product and marks a major step forward for the category. Mythocondro® solves any concerns related to the production origin, the possible presence of transmissible infective agents, the contaminations and adulterations typical of animal-derived raw materials and promises to completely change the global CS industry.

A Global Home for Kyowa Quality® Ingredients

Kyowa has launced a new website where consumers around the globe can find products with high quality Kyowa Quality Ingredients.

Consumers can easily search by brand, country or ingredients.

Check out the new website: www.kyowaquality.com 

 

PLT Health Solutions Appoints Michelle Jenkins as West Coast Territory Manager

PLT Health Solutions, Inc. announced the appointment of Michelle Jenkins as West Coast Territory Manager as a part of the company’s natural products industry sales team. Ms. Jenkins brings over a decade of experience in sales of branded nutraceutical ingredients, including stints at AstaReal, Blanver Farmoquimica and B&D Nutritional Ingredients to her new role at PLT.

 

According to Mark Stephens, Vice President of Sales at PLT Health Solutions, the appointment of Ms. Jenkins will bolster the company’s ability to develop innovative ingredient solutions for the company’s customers in the Western part of the United States. “At PLT, our sales team is called upon to manage relationships that engage in innovative product development and the creation of strong brands. Having experienced professionals like Michelle – who understand the importance of science-backed ingredient solutions – as part of our team helps us make sure our customers get PLT’s best,” he said.

Prior to joining PLT, Ms. Jenkins worked on the West Coast with astaxanthin producer AstaReal. Previous employment included positions as Western Regional Sales Manager for Brazil-based Blanver Faroquimica and nearly 10 years at B&D Nutritional Ingredients where she rose to Vice President of Sales

 

About PLT Health Solutions

Headquartered in Morristown, NJ, USA, PLT Health Solutions is a trusted discoverer, developer, and marketer of high-quality, scientifically-supported ingredients that enhance health and functionality. As a leading ingredients innovator, PLT’s global network of strategic partnerships provides unique access to impactful solutions. By delivering an unsurpassed mix of expertise, resources, and service, PLT is committed to helping both its strategic partners and valued customers grow.

 

Applied Food Sciences Issued Patent for Producing Guayusa Extract featuring Caffeine and Chlorogenic Acids

Applied Food Sciences, Inc. (AFS) is pleased to announce it is the exclusive owner of U.S. Patent #9345707, a process patent that covers the production of enriched natural guayusa, from a single source plant, containing antioxidants, amino acids and caffeine.  The purpose of this process patent is to create a highly water soluble energy ingredient for a healthier application of caffeine, chlorogenic acid antioxidants, catechins antioxidants, and trace elements of other nutritional compounds.  Guayusa extracts made with this patented process are easy to work with in formulation as a featured ingredient for an RTD tea-like beverage or used to produce a functionally enhanced beverage.

Guayusa – Ilex guayusa – (pronounced “gwhy-you-sa”) is a caffeinated leaf of the holly species that grows only in the upper Amazon region. Guayusa is not related to camellia sinensis used to make green or black tea varieties.  Instead, guayusa is a cousin plant to yerba mate. However, guayusa is uniquely different in that it tastes sweet, not bitter, and has a distinctively different polyphenolic antioxidant makeup.

In combination with this patent release, Applied Food Sciences is launching its newest branded ingredient offering, AMATEA™ guayusa extract – a highly water soluble ingredient for the application of focused energy intended in beverages and nutritional supplements.  AMATEA™ has a unique fingerprint standardized at 20% caffeine, 30% chlorogenic acids, 5% catechins, and contains other beneficial compounds.  Because it is low in tannins, AMATEA™ is not bitter, dry, or chalky tasting like many other more astringent tea extracts.  Instead AMATEA™ is naturally sweet to complement a variety of flavors.  AMATEA™ is also clear in solution, as well as non-GMO, GRAS (Generally Recognized As Safe), and organically grown.

“Customers are calling our guayusa ‘focused energy’ because the caffeine helps stimulate the mind while the polyphenol antioxidants balance that effect in the body,” says Brian Zapp, Director of Marketing at AFS.  “AMATEA™, therefore, is usually experienced as a bright and clear energy.  We see this offering meeting the growing demand of functional energy and cognitive health products that are geared toward modern working consumers seeking a calmer nervous system and less agitation to go with alert mental or physical energy.”

Applied Food Sciences recently published a white paper on AMATEA™ guayusa extract promoted in partnership by New Hope® Natural Media. This beautiful white paper gives more details on the history of guayusa and the science behind why this unique source of energy has been revered in the Amazon region for over a thousand years.

“AFS immediately started generating science to help researchers understand the synergies with caffeine among other naturally occurring compounds and how they impact physiological and hormonal biomarkers in the human body,” explains Chris Fields, AFS’ VP of Scientific Affairs.  “Initial clinical research utilizing AMATEA™, when compared to synthetic sources of caffeine, demonstrated guayusa’s ability to help regulate epinephrine upon caffeine ingestion.  This is significant because providing a conventional energy ingredient that typically works through stimulation of the central nervous system, like caffeine, with one that may help regulate neurotransmitter functions within the body, could be a critical benefit to the cognitive energy category.”

Mythocondro® shortlisted as Best New Ingredient at NutraIngredients Awards 2017!

Mythocondro®, the Non-Animal Chondroitin Sulfate of fermentation origin is finalist at NutraIngredients Awards 2017 in the Healthy Ageing category.

The pioneering vegetarian alternative confirms to be in the spotlight of the nutrition industry gaining another stage of great depth and significance. The NutraIngredients Awards are the celebration of the newness, cutting edge research and excellence of the year and takes place alongside the Vitafoods Exhibition, the leading nutraceutical event in the world. Being the finalist underlines the recognition of the ambitious target that Mythocondro® has reached to provide an animal-free long-awaited Chondroitin Sulfate.

The Awards ceremony will take place on May 10th at the Starling Hotel in Geneva… Let’s keep your fingers crossed with us!

Healthy Ageing, the hot and growing field

Healthy Ageing is a challenge and an opportunity at the same time. Globally, the number of older persons is growing faster than the numbers of people in any other age group. Between 2015 and 2030, the number of people in the world aged 60 years or over is projected to grow by 56 per cent, from 901 million to 1.4 billion, and by 2050, the global population of older persons is projected to more than double its size in 2015, reaching nearly 2.1 billion. (United Nations, Department of Economic and Social Affairs, Population Division (2015). World Population Ageing 2015 (ST/ESA/SER.A/390).

The definition of “healthy ageing” has been consolidated by the 1st World Health Organisation (WHO) global report devoted to ageing (2015): a ‘‘process of developing and maintaining the functional ability that enables well-being in older age’’. It is more than just the absence of disease; it is related to fighting against risk factors, for maintaining the functionality ability that enables well-being in older age. (Michel, J.-P. et al., European Geriatric Medicine , Volume 7 , Issue 4 , 298-305)

A major driver of the chondroitin sulfate market is the incidence of degenerative joint disease, also known as osteoarthritis. The disease commonly impacts joints which have been continually stressed, especially the knees, hips, fingers, and lower spine, leading to pain and loss of function. In the US, this figure reaches 19 million. Furthermore, according to the WHO, osteoarthritis will become the fourth most common cause of disability in the world by 2020 because of the progressive ageing of the population. (Woolf, A. and B. Pfleger, Bulletin of the World Health Organization, 2003. 81: p. 646-656)

Chondroitin sulfate is safe and efficacious for improving pain and functional capacity in people with osteoarthritis. The clinical benefits of CS have been established by a large number of human trials  which allows long term administration for OA and joint health.

Nowadays the global industrial production of chondroitin sulfate (CS) has been based on uses of animal tissue sources as raw material, derived from different species of animals (pig, bovine, avarian and fish) including shark cartilage.  Recent meta-analysis has demonstrated variable effects on osteoarthritis symptoms, yielding conflicting results mainly due to the high variability and poor quality of products used depending on the animal source. (McAlindon TE et al., JAMA 2000; 283: 1469–1475)

The challenge that Mythocondro® has won and that earned the nomination for the Awards is to provide a vegetarian alternative of chondroitin sulfate, free from the long-standing acknowledged problem of poor quality and potential safety issues of animal-derived CS, with the significant and higher  effectiveness in joint disease.

Innovation of Mythocondro® point-by-point

  • Produced by a natural and proprietary fermentation process
  • Very low protein content unlike animal-CS
  • Homogeneous structure similar to human chondroitin found in synovial fluid
  • A once-a-day dosage alternative to larger CS pills that need to be taken 2 times a day
  • High purity and constant quality profile guaranteed by tightly controlled, reliable and reproducible process
  • A demonstrated biological activity and established safety profile with published clinical trials
  • Low molecular weight and enhanced bioavailability
  • Extensive Intellectual Property
  • Vegetarian CS alternative for people with dietary and religious restrictions
  • Easy handling and storage, ideally suited for a broad range of products including: capsules and soft-gels for dietary supplements, conventional foods such as beverages and beverage bases, milk and milk products and chewing gum

Kaneka Pharma Europe presents Kaneka Ubiquinol and Glavonoid – with scientifically proven functions for use in health-improving and sports supplements

Brussels (Belgium), March 2017 – At this year’s Vitafoods, Kaneka Pharma Europe will showcase Kaneka Ubiquinol™, the most active form of coenzyme Q10.  Used as a nutritional supplement, the ingredient helps to prevent several diseases associated with aging. Thanks to its confirmed benefits on muscle performance and recovery, a number of professional athletes have already adopted Kaneka Ubiquinol™ as part of their training schedule. The company will also highlight the visceral fat-reducing and Novel Food-approved licorice root extract Glavonoid™, which has great promise for sports and fitness applications.

Besides Ubiquinol’s essential role in energy production, it is the only endogenously synthesised lipid-soluble antioxidant and therefore protects cell membranes from free radical damage. Its high bioavailability and bio accessibility enables Ubiquinol to be taken up by the body more quickly and efficiently than oxidized coenzyme Q10. Ubiquinol is scientifically proven to counteract several age-related ailments. Recently, in one of the largest ever studies, involving 1,911 subjects, Dr Frank Döring

[1] was able to demonstrate the function of Ubiquinol in gene expression: “People with low levels of Ubiquinol have higher levels of BNP and CRP, which are essential molecules of inflammatory processes and play an important role as risk factors for heart disease.” Ubiquinol is also vital for improving recovery in healthy individuals. The latest products target active “Best Agers” who want to stay healthy, as well as athletes who are keen to optimise their immune defences and muscular capabilities. Several European sports professionals have already started to use Kaneka Ubiquinol™, and its activity for athletes is backed by various scientific studies. Having thus far been mainly available in capsule form, Kaneka has now developed a stabilized Ubiquinol powder for use in powdered and liquid applications.

Furthermore, Kaneka will present the Novel Food-approved plant extract Glavonoid™, which was originally developed to prevent metabolic syndrome. Derived from licorice root (Glycyrrhiza glabra L.), Glavonoid™ has been proven to be completely safe and is approved by the European authorities with Novel Food ingredient status. An advanced, patented extraction process ensures that the ingredient does not contain any glycyrrhizinic acid, making it free from the unwanted side-effects of licorice. Glavonoid™ is able to increase the body’s own fat burning ability, while at the same time decreasing fat synthesis by down-regulating genes that are involved in fatty acid development. Since 2015, Glavonoid™ has been approved for extended use in foods for medical purposes and energy-restricted diets for weight reduction. A food supplement containing Glavonoid™ was now submitted for the Nutraingredients Award for best new weight management supplement of the year.

A recent randomized, double-blind, placebo-controlled study conducted in 2016[2] verified that Glavonoid™ can also increase skeletal muscle mass in humans in combination with exercise. During the study, male American Football athletes ingested 300 mg Glavonoid™ per day over 8 weeks of training. Ultrasound imaging analysis revealed that the muscle thickness of the anterior thighs and anterior brachial regions in the Glavonoid™ group were both significantly increased by 2.5% at week 8 in comparison to baseline. There was no such increase in the placebo group. Abdominal muscle thickness increased in both groups, but the increase was 1.8 times greater in the Glavonoid group than in the placebo group (p<0.05). It can therefore be seen that Glavonoid™ is ideal for inclusion in products aimed at the sports and fitness market.

 

[1] Fischer, A. et al.: Coenzyme Q10 redox state predicts the level of the c-reactive protein (CRP), a biomarker of inflammation, in a large European cohort. Biofactors 42(3):268-76.

[2] Myojin, C. et al.: Liquorice flavonoid oil increased skeletal muscle thickness as assessed by ultrasound in training football athletes. Nutrafoods 2016.

 

Kyowa Hakko named as a top-shelf ingredient company at Expo West / Engredea

Featured as an ingredient supplier not to be missed at this years Expo West / Engredea,  Kyowa offers several unique, branded ingredients that can be found in a wide variety of high quality products.