Dunedin, New Zealand and Saint Charles, MO USA – Blis Technologies and Stratum Nutrition announce a new clinical study on the effects of oral-cavity probiotic, BLIS M18™ (Streptococcus salivarius), on the development of dental caries in children.  The study was published in Clinical, Cosmetic and Investigational Dentistry (http://dx.doi.org/10.2147/CCIDE.S93066) and represents one of the pioneering attempts to analyze the significance of BLIS M18 in dental practice.  The results show that BLIS M18 significantly improves the chances of avoiding new dental caries.

This new randomized, controlled study on BLIS M18™ was conducted on seventy-six children between the ages of 6 and 17 that were classified as high-risk for dental caries on the basis of Cariogram results.  Cariogram is a well-recognized, clinically proven software program that looks at different caries-related risk factors to aid clinicians in performing consistent dental caries risk assessments.  Thirty-eight subjects (half) were supplemented for 90 days with a formulation containing the oral cavity probiotic BLIS M18 while the other half served as the control group receiving no treatment.  The study found that after 90 days of treatment with BLIS M18, there was a statistically significant reduction, by more than 30%, in the global Cariogram outcome, including parameters of “plaque amount” (50% reduction) and “mutans streptococci” (75% reduction).  These decreases are likely to be a direct consequence of the BLIS M18 bacteriocins’ interactions with mutans streptococci, as well as M18’s ability to colonize in the oral cavity and produce the beneficial enzymes dextranase and urease which are able to counteract plaque formation and saliva acidity. There was no statistical difference observed in the control group.  BLIS M18 also demonstrated a very good safety profile with no treatment-related side effects, as found in previous clinical trials.

Dr. Joseph Evans, Executive Manager of Research & Development for Stratum Nutrition, comments on the study: “Using an objective caries-risk assessment algorithm previously validated in children, young adults and seniors, the investigators have found that dietary supplementation with BLIS M18™ significantly increases the chances of avoiding dental caries in the coming year in children diagnosed as high-risk. Although requiring confirmation in a larger, controlled trial with development of caries as the primary outcome measure, these results suggest that BLIS M18 has the potential to complement a diligent oral hygiene program and nutritionally balanced diet in the ongoing battle against tooth decay.”

The mutans streptococci is one of the contributing factors to the development of dental caries, however its development can be disrupted by the activity of bacteriocins released by the BLIS M18™ probiotic.  Different strains of S. salivarius have been shown capable of counteracting the growth of mutans streptococci and of these, the strongest clinical potential has been shown by strain BLIS M18.

Previous trials evaluating BLIS M18™ have revealed its ability to colonize and persist in the human oral cavity, to reduce plaque formation, to lower S. mutans counts in school-aged children, and to modulate the gingival immune response in adults.  For more information on these studies, please contact Dr. Joseph Evans atJoseph.Evans@StratumNutrition.com.

Citation: Di Pierro F, Zanvit A, Nobili P, Risso P, Fornaini C. (2015) Cariogram outcome after 90 days of oral treatment with Streptococcus salivarius M18 in children at high risk for dental caries: results of a randomized, controlled study. Clin Cosmet Investig Dent. 7:107-113. http://dx.doi.org/10.2147/CCIDE.S93066

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About Us: Blis Technologies is the manufacturer of oral probiotic products based on the natural human mouth bacterium Streptococcus salivarius.  Stratum Nutrition is the exclusive North American distributor of BLIS probiotic products including BLIS K12 and BLIS M18. BLIS M18™ is a probiotic member of the bacterial species Streptococcus salivarius developed in Dunedin, New Zealand for the support of oral and dental health. Visit http://www.stratumnutrition.com/ingredients/blis-m18/ for more information on BLIS M18.

Applied Food Sciences’ New Ingredient, PurTea™, to Debut at Engredea in Natural Products Expo West

Boulder, CO —  Why make a new green tea extract? With advancements in technology and a better  understanding of how botanical relationships work with the human body, significant progress has been made in botanical extraction. For Applied Food Sciences, Inc. (AFS), it is about being able to take those benefits from nature and make them more bioavailable, better for you, and then bring it to consumers in a more convenient way. That is why AFS designed their latest ingredient PurTea™, a new organic green tea extract standardized for caffeine and catechins and designed as a novel natural source of energy for beverages.

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What makes PurTea™ so special? PurTea™ is water soluble and has less bitterness/astringency so it is easier to formulate within beverages. Furthermore, PurTea’s unique extraction process removes some of the more difficult compounds naturally found in tea that make beverage formulations challenging. PurTea™ was developed to provide a pure healthy source of energy and antioxidants.

“Applied Food Sciences selects only the finest organic tea leaves, free from pesticides and other harsh chemicals conventionally used in processing,” says Chris Fields, VP of Scientific Affairs at Applied Food Sciences. “What makes PurTea™ most unique is how we purify our catechin stream to remove impurities that not only create negative sensory attributes but may reduce the overall absorption of the catechins within the body. These catechins, when combined with the naturally occurring caffeine, can result in an enhanced energy source that is much more desirable to formulate within beverages.”

Another big point of differentiation in PurTea™ is that it is certified organic. With so much scrutiny over the definition of what determines a “natural ingredient”, consumers are becoming increasingly skeptic of what is inside the products they purchase. Many product makers are finding that certified organic ingredients are well-defined and thus easier to promote in bridging that gap of trust between consumers and their brands.

“Applied Food Sciences has a goal to genuinely fit a ‘Clean Label’ definition,” explains Jackson Zapp, VP of innovation at Applied Food Sciences. “That is why at Applied Food Sciences we have continued to pioneer organic extraction methods to help eliminate any questions about quality or safety. Our PurTea™ organic green tea extract is another great example of a naturally-sourced energy ingredient that consumers can recognize and trust.”

So why do all this for a commodity like green tea? According to a 2014 report summary by Grandview Research, Inc., notes that functional beverages account for the largest application for antioxidants from tea polyphenols, being more than 40% of total volume sold in 2012. That same summary notes that green tea is the source for 72.5% of those polyphenols (Tea Polyphenols Market Analysis By Application (Functional beverages, Functional food, Dietary supplements) By Product (Green tea, Olong tea, Black tea) And Segment Forecasts To 2020). Since there is a wealth of evidence related to the benefits of green tea compounds, research suggests that using green tea as a natural source of energy might enhance the stimulating effects of caffeine while mitigating negative effects associated with increased oxidation and cardiovascular instability. By decreasing the oxidation reactions taking place during increased energy expenditure green tea extracts can provide an ideal energy source to replace synthetic caffeine. There are some obvious challenges when working with green tea ingredients especially in formulating functional beverages. For Applied Food Sciences, it is about simply making it easier to use and better for you.

Applied Food Sciences
Austin, Texas-based Applied Food Sciences, Inc. (AFS) is a health and wellness organization that specializes in organic and naturally sourced botanicals such as organic caffeine, organic green tea, guayusa tea, and green coffee extracts. Applied Food Sciences, provides some of the largest global companies solutions in health & wellness, sports nutrition, and clean energy. For more information visit our website www.appliedfoods.com or call +1-800-345-9666, AFS is also exhibiting at VitaFoods, Geneva, Europe and BevNET Live in NY.

Dr. Ajax Mohamed has been named Resident Director, Sabinsa Europe GmbH, the EU division of the Sami-Sabinsa Group of companies. That division just marked its 10^th Anniversary with a Sabinsa on Wheels scientific conference.

Dr. Mohamed holds a Doctorate Degree in Chemistry from AMU, Aligarh, India. In 1998 he became a DAAD fellow at George August University, Göttingen, Germany for post-doctoral research, which he later continued at Goethe University at Frankfurt.

Dr. Mohamed has over 20 years of experience in R&D, technical sales and marketing. After completion of his research work, Dr. Mohamed joined an international company in Frankfurt, Germany as Sales and Marketing Manager. Before joining Sabinsa Europe in 2008 as Vice President – Sales, he headed the business-consulting unit of a Frankfurt based company. For the last six years Dr. Mohamed has also handled marketing and sales activities in Europe for Sami-Sabinsa group’s associate company Organica Aromatics Ltd., which manufactures high quality Aroma chemicals and Perfumery compounds.

“Dr. Mohamed combines a deep scientific background with Sabinsa’s other hallmark, working closely with customers to support their production of safe and effective Nutraceutical and Cosmeceutical products,” said Sabinsa-Sami founder Dr. Muhammed Majeed. “We’re pleased to have his talents and expertise helming Sabinsa Europe.”

About Sabinsa Corporation
Sabinsa’s mission is to provide alternative and complementary natural products for human nutrition and well being. Over the past 27 years, Sabinsa has brought to market more than 100 standardized botanical extracts, and privately funded clinical studies in conjunction with prestigious institutions in support of these products. With more than 100 full-­‐time scientists conducting ongoing research in India and the United States, Sabinsa and parent company Sami Labs Ltd. continue to develop, patent and manufacture phytonutrients for the world market, with ingredients that are both Halal and osher. Branded Ingredients by Sabinsa.

Fytexia is preparing to release for the first time the new results from a second clinical study on 92 subjects over 16 weeks on the natural ingredient Fiit-ns^®, synergy of polyphenols and vitamin B3 targeting Quality of Life improvement.

These results will be introduced at the Healthy Aging Webinar hosted by Nutra-ingredients.com on the March, 29th at 2:30pm (Paris time).

Register HERE to attend the Webinar and receive your copy of the clinical results after the event

Sabinsa Europe GmbH hosted Sabinsa on Wheels, a day-long science summit on Zugspitze, the highest mountain in Germany, on Wednesday March 16, 2016. In addition to presenting the latest clinical studies conducted on Sabinsa’s proprietary dietary supplement ingredients in popular health categories and cosmetic segments, industry experts offered their perspectives on timely industry subjects. The sessions drew 40 R&D experts from throughout Europe. This edition of Sabinsa’s renowned scientific retreats marked the 10th anniversary of Sabinsa Europe GmbH.

Guest speakers and topics included:

• Dr. Jorg Grunwald, Analyze & Realize, Berlin, discussing new food and supplement ideas with plant extracts.
• Dr. Cedric Bourges, Nutraveris, France, presented “Regulatory Landscape For Food Supplements In Europe: Basis And Evolution In This Complex But Necessary Area.”

Speakers from Sabinsa, presenting on topics ranging from curcumin research, probiotic stability, inflammation and cosmetic ingredients, included:

• Nagabhushanam Kalyanam, PhD, President of R&D, Sabinsa
• Dr. Ajax Mohammed, Vice President, Sabinsa Europe
• Dr. Umar Jan, Technical Sales Manager, Sabinsa Europe

“The Sabinsa on Wheels program presents an unique opportunity to give our customers in-depth information in person about the science supporting Sabinsa’s ingredients and technologies, and we were pleased to see such good attendance” said Dr. Ajax Mohammed, Vice President, Sabinsa Europe. “We very much appreciated our esteemed special guest speakers sharing their insights.”

Attendees stayed at the Eibsee Hotel in Grainau the night before, adjacent to the ancient towns of Garmisch-Partenkirchen, and took a cable car to Zugspitze for the program. The Zugspitze is the highest mountain in Germany, home to three glaciers and Germany’s highest ski resort. Right at the top, an impressive 360° panorama opens up to reveal extensive views over 400 mountain peaks in four countries.

About Sabinsa Corporation
Sabinsa’s mission is to provide alternative and complementary natural products for human nutrition and well being. Over the past 27 years, Sabinsa has brought to market more than 100 standardized botanical extracts, and privately funded clinical studies in conjunction with prestigious institutions in support of these products. With more than 100 full-­‐time scientists conducting ongoing research in India and the United States, Sabinsa and parent company Sami Labs Ltd. continue to develop, patent and manufacture phytonutrients for the world market, with ingredients that are both Halal and osher. Branded Ingredients by Sabinsa.

Researchers with the University North Texas have examined optimized curcumin [Longvida^®] supplementation as therapy for Exercise-Induced Muscle Damage (EIMD) and Delayed Onset Muscle Soreness (DOMS) impact post training and Activities of Daily Living (ADL). The study was intended to determine the effects of 400mg/day of Longvida® Optimized Curcumin “on muscle and ADL soreness, creatine kinase (CK), and inflammatory cytokines (TNF-α, IL-6, IL-8, IL-10) following exercise-induced muscle damage .”

Twenty-eight participants were randomly assigned to either 400mg/day supplementation of Longvida^® or placebo, then participated in a leg press exercise. Blood samples were taken before the exercise, and at one, two, three, and four days post exercise. These were used to measure and analyze creatine kinase (CK) and inflammatory cytokines, which were analyzed by ANOVA with p<0.05.

The study notates: “Curcumin supplementation resulted in significantly smaller increases in CK (-48%), TNF-α (-25%), and IL-8 (-21%) following EIMD compared to placebo. We observed no significant decreases in IL-6, IL-10, or quadriceps muscle soreness between conditions for this sample size.” Based on these results, a larger sample size should be examined to see if the trending lowering effect of these other markers could be significant.

Additionally, the findings indicated that the consumption of Longvida^® Optimized Curcumin reduced inflammation, but not quadriceps muscle soreness during recovery post induction of exercise muscle soreness. Dr. McFarlin states, “The observed improvements in biological inflammation may translate to faster recovery and improved functional capacity during subsequent exercise sessions.”

In summary, researchers’ findings, “support the use of oral curcumin supplementation [as Longvida^® Optimized Curcumin] to reduce the symptoms of EIMD.” ¹ Sonya Cropper, VP of Marketing & Innovation with Verdure Sciences, stated, “I am pleased to see additional support of Longvida’s efficacious capability to promote active lifestyle activities. It is impressive to see a second clinical that supports Longvida’s impact on particular biomarkers that influence health.” ^†

About Longvida^®
Patented Longvida^® Optimized Curcumin was developed by Verdure Sciences^® in collaboration with UCLA neuroscientists with over ten years of bioavailability, efficacy, and safety testing. Longvida^®’s SLP™ Technology is able to reach target tissues offering efficacious levels of free curcumin at a low daily dose. Longvida^® (US Patent 9192644, EP Patent 19933665; additional patents pending) is a registered trademark of Verdure Sciences^®, Inc. SLP™ and SLCP™ are trademarks of Verdure^® Sciences, Inc.

Visit Longvida.com for more information

About Verdure Sciences^®
Verdure Sciences manages ingredient innovation throughout the integration of supply network, production, and research platforms. With an expanding pipeline of proprietary, standardized botanical ingredients supported by pharmacokinetic, pharmacodynamic, and clinical research profiles, we work toward our unified vision to offer safe, effective ingredient solutions. Verdure Sciences^® is a registered trademark of Verdure Sciences^®, Inc.

Visit VS-Corp.com for more information

References
¹McFarlin BK et al. Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin. BBA Clinical. 2016 February 17. DOI: 10.1016/j.bbacli.2016.02.003

^† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

For additional information: http://www.sciencedirect.com/science/article/pii/S2214647416300034

TeaCrine^® is now the best-selling energy/cognitive ingredient with the renowned Informed Choice/Informed Sport certification.

Compound Solutions, Inc. (CSI), exclusive global distributor of patent-protected TeaCrine®, today announced explosive sales numbers. The announcement comes after a 2015 fiscal year that saw the premium, branded ingredient grow from three product launches in 2014 to 53 in 2015—and a further 32 in just the first quarter of 2016. CSI expects growh to continue at this extraordinary pace.

TeaCrine^®, the clinically studied, pure, bioidentical form of theacrine, has quickly become the best-selling energy/cognitive ingredient certified to be free of banned substances by Informed Choice and Informed Sport. It’s now found in iconic brands such as Cellucor®, Muscle Pharm^®, ProSupps^®, Performix^®, MyProtein^®, USN Sports Nutrition^®, Nutrex^®, EVL^®, Beast Sports^® and BSN^®. And TeaCrine’s^® combination of efficacy and safety has opened doors into new markets as it continues to deliver on its promise to provide a natural way to revolutionize physical and cognitive performance.

Matt Titlow, CEO of Compound Solutions, responded to the annnouncement. “We’ve seen staggering growth, first and foremost, because TeaCrine^® works. And that’s giving us strong brand recognition and significant advantages.”

TeaCrine^® enjoys several regulatory advantages over non-DSHEA compliant ingredients. Recently the FDA, DOJ, FTC, and even multiple state attorneys general have taken civil and criminal action against companies using various non-DSHEA compliant ingredients that lead to misbranding and adulteration of finished dietary supplement products. These include Picamilon (aka Pikatropin), DMAA and AMP Citrate (DMBA), Acacia Rigidula, Synephrine 30%, and others on the watch list include various synthetic HCl PEAs (e.g., BMPEA,N-dimethylphenethylamine, N-benzyl-2-PEA, 2-amino-isoheptane HCl) Vinpocetine, and more.

By investing nearly $1,000,000 in human and animal clinical data, TeaCrine^® has established both safety and efficacy in a market riddled by non-compliant and counterfeit products. And that has lead to to a self-affirmed Generally Recognized As Safe status (GRAS) pending the upcoming publication of its seminal 90-day safety study.

“In a regulatory environment where every energy ingredient is scrutinized, we are proud to say we’ve invested a large amount of money into the safety, efficacy, sensory, IP and comprehensive regulatory platforms of TeaCrine^®,” Titlow said. “But that’s just the start. You’ll see in just the next couple months that we’re continuing to broaden TeaCrine’s potential applications and validate new claims.”

TeaCrine’s^® efficacy and expanding applications have lead to widespread apdoption as demand across multiple categories continues to exceed expectations and fuel additional growth. Sports, nootropics, gamers, “biohackers,” life extensionists, police/fire/military personnel, and busy professionals are currently using TeaCrine® as a safe, effective way to maximize physical and cognitive potential.

“This is much more than a simple supplement,” said Titlow. We see this as a revolution in energy and cognitive performance, and we anticipate a long, bright future for TeaCrine^®.”

Compound Solutions, Inc. is the go-to company representing and distributing unique, patented nutraceutical ingredients for the sports nutrition, functional food and beverage and nutritional supplement markets. Compound Solutions is the exclusive global supplier of TeaCrine^®.

Gnosis is truthfully proud to announce a great confirmation and success obtained from Superesse^®, the enriched natural yeast with S-Adenosylmethionine (SAMe) that states the importance of SAMe (Adomet^®) as nutritional driving compound, and the leading role of Gnosis in developing products based on S-Adenosylmethionine.

The Japanese Ministry of Health, Labour and Welfare (MHLW) has granted an health claim to Gnosis’ SupereSSe^®. The grant of the health claim, which refers to “Improvement for the joint wrongness”, has a peerless importance and is having rather big reaction from Japanese market.

This achievement is very impressive especially because, Japan is a thought leader in the manufacture and use of “Foods with Health Claims” – the preferred term for dietary supplements and natural nutraceuticals in Japan.

The health-conscious Japanese have long embraced the benefits from nutraceuticals, and the country ranked third in per capita spend on nutraceuticals in 2014 according to World Health Organization (WHO) data, while others place Japan as the second largest individual consumer of nutraceuticals (behind the U.S.).

“For regulatory purposes, nutraceuticals in Japan are heavily regulated so achieving an health claim in Japan is extremely hard” said Paolo Malesani, Commercial director of Gnosis Group – “but that confirm the SupereSSe® outstanding nutritional value has been recognized for the improvement of joint wrongness”.

The scientific efficacy of the SAMe SupereSSe^® has been proven through a human clinical study – placebo-controlled double-blind randomized clinical trial – to reduce knee discomfort. The study has been published on Japan Pharmacology & Therapeutics in 2015.

(Yamanaka N. et al. “The effects of SAM-e yeast to improve the discomfort of knee in healthy adults” Jpn Pharmacol Ther 2015; 43:549-59)

For more information contact:
marketing@gnosis-bio.com

Austin, TX – Chemi Nutra proudly announces the introduction of novel, water dispersible specialty phosphatidylserine (PS) and phosphatidic acid (PA) phospholipid ingredient compounds, for use in applications including beverages, RTDs, shots, and gels, while providing documented, unique health benefits.

SerinAid^® Disperse 3.0F contains Chemi’s patented, water dispersible PS, notable, as PS is considered one of the safest, most scientifically studied natural compounds for maintaining and improving cognitive abilities – concentration, learning, memory, recall, and focus – as well as benefiting dementia, mood, stress, and behavioral attention deficits. PS has been granted two qualified health claims by the FDA, related to cognitive dysfunction and dementia in the elderly.

Mediator^® Disperse 7.5F contains Chemi’s patented, water dispersible PA, scientifically proven to significantly activate the mechanistic target of rapamycin (mTOR) signaling pathway, which in turn regulates both muscle protein synthesis and muscle protein breakdown – in essence, providing increased muscle mass and strength gains to individuals engaged in muscle stressing type exercise.

These specialty water dispersible compounds were developed in collaboration with 3i Solutions, Wooster, OH, the world leader in ingredient nanodispersion technology. “About 20 years ago, we
began working with 3i Solutions to perfect a stable, highly bioavailable, water dispersible, liposomal PS. With 3i Solutions’ demonstrated capabilities and our combined application
knowledge in functional drinks, we are very excited that SerinAid^® Disperse PS and Mediator^® Disperse PA can now be easily and effectively added to functional beverages, a rapidly evolving segment in the functional foods and sports nutrition arenas”, said Scott Hagerman, president of Chemi Nutra.

Charles Brain, president of 3i Solutions, said, “We have enjoyed partnering with Chemi Nutra, the most prominent company in production, research, and sales of specialty phospholipid ingredient
compounds, in this exciting project. Using our proven, proprietary technology, we are thrilled that Chemi Nutra is first-to-market with true, high quality, water dispersible PS and PA ingredients. We are excited that 3i Solutions can offer our long history of expertise in nanodispersion technology in the functional beverage and RTD arenas.”

Chemi Nutra is the U.S. business unit of parent company Chemi S.p.A., a privately held pharmaceutical and nutraceutical company based in Milan, Italy. Chemi, with cGMP certified manufacturing facilities in Italy and Brazil, is best known in the global nutritional arena for its introduction of SerinAid^® PhosphatidylSerine (PS) and AlphaSize^® Alpha-Glyceryl Phosphoryl Choline (A-GPC), patented, well researched, health benefiting dietary supplement ingredient compounds, which are widely used to enhance learning, memory, and concentration, exercise performance, power output, youthful wellbeing, and to reduce stress.

Contact Chemi Nutra

Gnosis is pleased to announce that on February 16^th, 2016 Quatrefolic®, the biologically active form of the naturally-occurring predominant form of folate, has been approved as food additive by the Ministry of Health of the People’s Republic of China (MOH).

In the next months Quatrefolic® will be officially listed in the regulation GB 2760-2011-NATIONAL STANDARD OF FOOD SECURITY: Usage Standard of Food Additives, in the category related to Instant Drinks preparation.

Chinese food additives regulation verified that Quatrefolic® is proven to be safe according to international protocols, and covers the national applications for food safety standards, in reference to the list of allowable food additives of the Ministry of Health, and to the scope of allowed applications and dosage levels.

Instant drinks are relative and are very popular among the all age group in China. Their use are growing because they have mostly good taste and nutritional value and making active ingredients easy to dose and to swallow. Quatrefolic® suits instant drinks preparation because dissolves instantly in water and sustains a rapid absorption in the gastrointestinal tract.

The instant drinks are becoming more popular all over the world, they are perfect for health conscious people who demand to consume healthy beverage because are generally without artificial flavorings, sweeteners, additives or preservatives, normally required and used in drinkable dosages.

They also allows to combine different actives that are not compatible in a powder or liquid combination.

By combining three different pillars of ingredient versatility – easy handling, room stability and high water solubility – Quatrefolic® owns extended formulation flexibility and is suitable to satisfy the easy-to-use market demands of manufacturers and consumers, fulfil their expectations. Quatrefolic® demonstrates a surprisingly high solubility in water –greater than 1 g/ml – compared with the poor solubility of the 5-methyltetrahydrofolate calcium salt.

The versatility of Quatrefolic® is attested by the several finished products in worldwide market which include conventional solid dosage forms such as tablets capsules, microencapsulated powders and granulates but also easy-to-go formulations in sachets or sticks to be used “as is” or dissolved in instant drinks, according to the field of application and the target of consumers.

Gnosis is pleased to announce that on February 16th, 2016 Quatrefolic® has been approved as food additive by the Ministry of Health of the People’s Republic of China (MOH).

For more information contact:
marketing@gnosis-bio.com