New Rat Study from University of Connecticut Medical Center

New Brunswick, NJ – Natreon’s Capros^®, a clinically studied and standardized aqueous extract of Phyllanthus emblica, has shown to preserve cardiac tissue during ischemia-reperfusion injury in rats according to a study just published in The Journal of Physiology and Biochemistry.

This study was designed to examine the effect of Capros^® treatment on myocardial ischemia-reperfusion (I/R) and identify the molecular targets and its underlying mechanisms. Experimental animals were divided into four groups: control sham (CS), P. emblica sham (PS), control I/R (CIR), and P. emblica I/R (PIR). Rats in the P. emblica groups were gavaged with aqueous P. emblica solution (100 mg/kg body weight) for 30 days. After 30 days of gavaging, the I/R group underwent I/R surgery (45-min ischemia) followed by 4 or 30 days of reperfusion. Rats in the sham group underwent surgery without ligation. Left ventricular tissue samples, 4 and 30 days after I/R, were used for Western blot analysis and immunohistochemistry, respectively. Echocardiography showed increased ejection fraction and fractional shortening and decreased left ventricular internal diameter in experimental subjects compared to controls. There was decreased fibrosis in P. emblica-treated rats compared to controls. The results of this study indicate that P. emblica is capable of upregulating the PI3K/Akt/GSK3β/β-catenin cardioprotective pathway, thereby preserving cardiac tissue during ischemia-reperfusion injury.

Capros^® is a FDA GRAS approved, non-GMO, vegetarian ingredient derived from the edible fruits of Phyllanthus emblica. Previous randomized, double blind, placebo-controlled studies with Capros^® treatment have shown significant benefits for cardiovascular health. These studies showed significant improvements in endothelial function by increasing production of nitric oxide by more than 50%. A significant decrease in the inflammation biomarker hsCRP by more than 50% was noted in these studies. In addition, triglyceride levels decreased, LDL decreased, and HDL increased in patients treated with Capros^®. Capros^® is a super antioxidant that is water soluble and stable; thus, it is an ideal product for addition into hot and cold beverages and functional foods.

About Natreon Inc.
Natreon Inc. is a 16 year old company located in New Jersey with a state of the art R&D facility in Kolkata, India, and is focused on developing and marketing Ayurvedic products backed by extensive research, high degree of standardization, multiple clinical studies, safety studies, and intellectual property. Natreon’s R&D team is headed by Prof. Shibnath Ghosal, a Fulbright scholar and an eminent natural product chemist with hundreds of publications in scientific journals and a group of Ph.D. and Master’s level scientists. Natreon’s scientific research includes process optimization, development of chromatographic analytical methods such as HPLC, HPTLC, GC-MS and LC-MS for standardization, development of marker compounds, and pharmacological studies. Safety studies are done in the USA and clinical studies are conducted in reputed institutes in India as well as the USA.

For more information on Capros^® and Natreon’s other patented ingredients, please visit www.natreoninc.com.

Rimouski (Quebec) – innoVactiv, a Canadian company dedicated to the development of science-based specialty ingredients, today announces that it is joining forces with FrauPharma srl to offer NeuroPeak PS^® ingredients to North American dietary supplement manufacturers. The commercial launch of this new product line is planned at the upcoming SupplySide West tradeshow (October 7-8, Las Vegas, NV).

Founded in 2011 by Dr. Francesco Autuori, FrauPharma established its headquarters and production facility in the outskirt of Milan (Italy), in a region known as a center of excellence in the active ingredients industry. FrauPharma products are manufactured in its state-of-the-art pharmaceutical cGMP facility. “Our certifications are the highest and strictest that ingredient manufacturers can obtain and ensure dietary supplement manufacturers that they get only the quality, consistency and reliability they deserve”, said Dr. Autuori.

“innoVactiv has been consistently looking to add new and innovative specialty ingredients to reflect our growing commercial presence. Given our enviable reputation and our commitment to our customers, we wanted to make sure any company we would partner with would abide by the same levels of excellence and dedication. That is what we found in FrauPharma”, said Patrice Dionne, CEO of innoVactiv.

This partnership positions innoVactiv as a true value-creator in the North American ingredient marketplace. “NeuroPeak PS^® various potencies with quality levels that will certainly meet or exceed expectations of supplement manufacturers. We are thrilled to launch these new ingredients at SupplySide West and would love to invite all interested manufacturers at Booth #1669 or to set up a meeting in advance with us during the event”, said Jocelyn Bérubé, Executive & Scientific Director, Health & Nutrition of innoVactiv.

About innoVactiv
innoVactiv’s mission is to develop and supply innovative health ingredients with scientific demonstrations of efficacy and safety for the nutraceutical and cosmeceutical industries.

How to Compete in the Sports Nutrition Sector

Summary
Athletes and people with active lifestyles often experience respiratory tract symptoms (RTS), and many struggle with recurring upper respiratory tract infections (URTIs). The result is disrupted training schedules and poor physical performance. A strong immune defence is key to avoid performance setbacks caused by unwanted common bacterial and viral infections.

These consumers are well aware of the importance of a balanced diet, and put more than average effort into diet management to ensure that the body’s nutritional demands are met. For a sports nutrition product to stand out from the crowd and catch the attention of this group, it must offer something extra – something of additional value.

The paper reviews the scientific literature on immune health and athletic performance, and makes the case for beta-1,3/1,6-glucan as a valuable immune health ingredient in sports nutrition products – for the consumer as well as for the manufacturer.

Download the White Paper here:
Nutramunity – White paper – Immune Health and Sports Nutrition

About Nutramunity™
Nutramunity™ Beta-Glucan (NBG®) is a versatile immune health ingredient suitable for foods, beverages and dietary supplements. Nutramunity™ may also be used as a cosmetic ingredient in personal care products. Nutramunity™ is a beta-1,3/1,6-glucan, a potent and safe immune-enhancing component isolated from baker’s yeast (Saccharomyces cerevisiae) that helps support healthy immune function. Nutramunity™ is naturally-derived, non-GMO, kosher and halal-certified, allergen-free, GMP-produced, and EU Novel Food-authorized. Yeast beta-1,3/1,6-glucan is US FDA GRAS-recognized. Learn more at www.nutramunity.com.

St. Charles, MO – Stratum Nutrition in collaboration with the Traditional & Biomedical Research Center within Daejeon University and Ju Yeong NS Co., Ltd., is pleased to announce a new research study on NEM^® brand eggshell membrane has been published. The study further validates NEM’s mechanism of action and reveals exciting insights on NEM’s ability to support joint health.

Researchers evaluated three doses of NEM (including the human equivalent dose of 52 mg/kg) in a rat model of osteoarthritis. As in prior research, NEM again demonstrated powerful anti-inflammatory effects, in this case on the inflammation biomarkers Interleukin 1-beta (IL-1β) and C-Reactive Protein (CRP). And, for the first time, chondroprotective effects were revealed from NEM treatment. NEM was found to reduce circulating cartilage degrading enzymes known as Matrix Metalloproteinases (MMPs) and was shown to reduce serum levels of the cartilage degradation biomarker CTX-II. Importantly, the demonstrated chondroprotective effects were validated through histology, wherein a blinded pathologist evaluated cartilage thickness and joint space width both microscopically and via micro CT scan. The results of this study were published in the August issue of the Journal of Nutrition and Health (DOI: http://dx.doi.org/10.4163/jnh.2015.48.4.310).

“The Korean researchers did a wonderful job of demonstrating the myriad benefits that NEM offers to arthritis sufferers. We are particularly excited about the chondroprotective effects shown with NEM and we have filed patent applications internationally surrounding this use for eggshell membrane,” commented Dr. Kevin J. Ruff, Sr. Director of Scientific & Regulatory Affairs for Stratum Nutrition which distributes NEM globally.
This study, along with additional published studies, show further substantiation for NEM^® supporting a healthy inflammatory response. For more information on this new published data, please contact Dr. Kevin Ruff at kruff@esmingredients.com.

About Stratum Nutrition
Stratum Nutrition, a Novus International Business, is Empowering Product Innovation through functional and specialty ingredients for manufacturers and marketers of foods, beverages and supplementation. Stratum offers a portfolio of branded, value-added ingredients that are progressive, safe and reliable. These ingredients are based on consumer need, supported by science and the backing of a trusted multinational company. Visit www.StratumNutrition.com for more information.

Study is highlighting its efficiency in the reduction of cellulite by oral route

Avignon (France) – On the occasion of the Supply Side west 2015 event, BIONOV will introduce its latest developments and innovations. A new clinical study on its melon juice concentrate SOD B Dimpless^® has now been accepted for publication in the journal Phytothérapie.  This study shows that SOD B Dimpless® significantly reduces cellulite on thighs after 28 days of oral supplementation on 21 women. The mechanism of action involves both fibrosis resorption and lipolysis stimulation, allowing to correct the skin dimpling aspect.

Clinically proven efficacy
The efficiency of SOD B Dimpless^® has been shown in a double-blind, placebo-controlled clinical study accepted for publication in Phytothérapie. This clinical study, performed on 41 women under dermatological control, demonstrates a significant visual reduction of cellulite on thighs by -9.5% after only 28 days of supplementation at 40 mg/day, i.e. 480 IU SOD/day. SOD B Dimpless® clinical efficiency is maintained and even emphasized after 56 days of supplementation with a significant reduction of cellulite on thighs by -11.3%.

An innovative targeted action on cellulite
Cellulite is a major beauty issue affecting more than 90 million women in USA and 1.7 billion worldwide. SOD B Dimpless^® is ideally suited to reduce cellulite thanks to unique an efficient dual action. Highly concentrated in SuperOxide Dismutase (SOD), a key antioxidant enzyme largely studied for its action against fibrosis in more than 130 publications, SOD B Dimpless^® fights both the fibrosis state of the connective tissue, and the fat cells hypertrophy, identified as the two main cause of cellulite development. This innovative way of action guarantees a significant quick and lasting reduction of the orange-peel aspect.

In & Out efficiency
Produced by Bionov (France), SOD B Dimpless^® is a dried melon juice concentrate highly guaranteed in SuperOxide Dismutase (SOD, 12,000 IU/g). SOD is a primary antioxidant enzyme which represents the body’s first line of defense against free radical damages. Protected from gastric degradation thanks to a patented microencapsulation technology, SOD B Dimpless is adapted to the formulation of both nutritional and cosmetic applications:

• Nutrition: capsules, softgels, tablets, gums, instant drinks
• Cosmetic: creams, lotions, ointments

SOD B Dimpless^® is produced by:

Distributed in the USA by:

Probiotics Popped Up Across Many Unexpected Product Categories at This Year’s Show

CLEVELAND, OH – The recognized innovator in probiotics is celebrating the unveiling of 7 new products fortified with the patented probiotic, GanedenBC³⁰, at Natural Products Expo East.

The demand for probiotics continues to drive innovation in the food and beverage industry. Consumers want to support their healthy lifestyle with probiotics, but they want to avoid taking another pill. They want the health benefits in products that they already enjoy. This consumer demand has led to brands pushing the innovation envelope by taking advantage of the unrivaled formulation capabilities of the spore-forming, probiotic, GanedenBC³⁰, to offer consumers new, exciting, and unexpected ways to get their daily dose of probiotics. Juices and protein powders continue to be “hot” probiotic categories, but this year’s Expo East introduced first-of-its-kind probiotic products such as a buttery spread, almond butter, and even chewing gum!

Introducing the 7 newest products showcasing the exceptional formulating capabilities of GanedenBC³⁰:

• Probiotic MELT Organic Buttery Spread – Made from the Perfect Blend™ of “good fats” like virgin coconut oil plus probiotics, Probiotic MELT supports digestive health and a healthy immune system as part of a balanced diet and healthy lifestyle. Even better, Probiotic MELT delivers active cultures more effectively than yogurt. Probiotic MELT enhances the flavor of the foods you love while delivering probiotics safely and deliciously. Just two servings, or two tablespoons, per day supports your digestive health. For more information, please visit MeltOrganic.com.
• Temple Turmeric Seasonal HPP Beverages – Two flavors: Holiday Spiced Lassi – this enlightened vegan preparation is brimming with mango, coconut milk, quinoa, hemp and holiday-inspired ingredients like tart cranberry, sweet fiber-rich dates, and spicy cardamom. Pure Fire Cider – Deeply rooted in folklore and tradition, this modern take boasts tart, fiery apple cider vinegar, heat-stimulating ghost pepper, horseradish and ginger — all balanced by the delicate sweetness of orchard-fresh apple cider — plus 1 billion CFU per serving of GanedenBC³⁰ probiotics to support digestive and immune health. For more information, please visit TempleTurmeric.com.
• Beveri Probiotic Whey Protein – A Whey Protein that is exclusively Whey Protein Isolate (WPI), the purest form of whey protein. It’s lactose free, fat free and contains 0g sugar. Beveri whey protein is enriched with GanedenBC³⁰ which helps support your immune system health. Five flavors: Key Lime, French Vanilla, Coconut, Strawberry, and Chocolate Fudge. For more information, please visit BeveriNutrition.com.
• Yumbutter Probiotic Plant Protein Almond Butter – A creamy, Non-GMO, sprouted plant based protein almond butter packed with allergen free GanedenBC³⁰ probiotics. For more information, please visit Yumbutter.com.
• Harvest Soul ProBiotic Juices – Introducing a USDA organic blended fruit and vegetable juice with the goodness of GanedenBC³⁰ probiotics. Harvest Soul’s juices come in 4 flavors, contain blended whole fruits and veggies, and are Non-GMO, gluten free, BPA free, no sugar added, and contain 2 billion CFU’s of GanedenBC³⁰. For more information, please visit HarvestSoul.com.
• Vital Proteins Collagen Whey Protein – This advanced protein utilization formula combines collagen with grass fed whey protein, fermented cocoa bean flavonols, GanedenBC³⁰ probiotics, and natural hyaluronic acid to achieve a natural premium protein blend which tastes great. For more information, please visit VitalProteins.com.
• XyloBurst PURE Probiotic Gum – An allergen-free gum formulated to support a healthy immune system. With the addition of xylitol, PURE probiotic gum also helps to promote oral health while you freshen your breath and support a healthy immune system. GanedenBC³⁰ probiotics assist in restoring a healthy balance of good bacteria in the digestive tract as part of a balanced diet and healthy lifestyle. For more information, please visit FocusNutrition.com.

About GanedenBC³⁰:
Introducing GanedenBC³⁰® (Bacillus coagulans GBI-30, 6086), Ganeden’s patented probiotic ingredient that can be found in more than 100 leading food, beverage, sports nutrition and companion animal products around the world. Unlike most other probiotic strains, GanedenBC³⁰ is a spore-former which makes it highly stable and allows it to remain viable through most manufacturing processes, three years of shelf life and the low pH of stomach acid. The efficacy of GanedenBC³⁰ is backed by over 20 published studies showing digestive and immune support and GanedenBC³⁰ has an exceptional safety record with FDA GRAS status from the United States FDA. It can be formulated into virtually any food, beverage or companion animal product that is baked, boiled, frozen or squeezed…. including all hot or refrigerated beverages! For more information, please visit GanedenBC30.com.

About Ganeden:
Ganeden is at the forefront of probiotic research and product development with an extensive library of published studies and more than 100 patents for probiotic technologies in the food, beverage, animal health, sports nutrition and personal care ingredients markets. Ganeden is best known for GanedenBC^30® (Bacillus coagulans GBI-30, 6086), its patented, FDA GRAS, non-GMO, highly stable probiotic ingredient. Ganeden’s newest ingredient, Bonicel, is the first science-backed, probiotic-derived, personal care ingredient shown to dramatically reduce signs of aging. For more information about Ganeden and licensing opportunities visit GanedenProbiotics.com.

Another acquisition in Natural Ingredients – continues strengthening its position as a leading global player in this field

Nutrafur has impressive r&d capabilities, a quality workforce and a plant with significant expansion potential

Herzliya, Israel – Frutarom Industries Ltd. (“Frutarom”), one of the world’s 10 largest companies in the field of flavors and specialty fine ingredients, continues its momentum of acquisitions and the implementation of its rapid and profitable growth strategy: the Company announced today the purchase of 79% of the shares of the Spanish company Nutrafur S.A. (“Nutrafur”) based on a company value of approx. US$ 14.5 million (€ 13.1 million). The transaction was completed upon signing and is being financed with bank credit. Nutrafur specializes in the research and development, manufacture, and sales and marketing of specialty natural plant extracts bearing antioxidant properties or scientifically proven healthy qualities and supported by clinical studies for the food, pharma, nutraceutical and cosmetics markets. Nutrafur sales for the 12-month period ending June 2015 amounted to approx. US$ 13 million. The value of Nutrafur’s net assets for 30.6.15 on a cash-free debt-free basis stood at approximately US$ 11.4 million.

Nutrafur has accumulated many years of know-how and excellent capabilities in the extraction of active components from vegetation, particularly rosemary, olive and citrus. Nutrafur products blend in well with Frutarom’s portfolio of natural ingredient solutions and will help expand Frutarom’s lineup of natural products for both food and health products. Nutrafur’s activity in the field of antioxidants, particularly in the area of food preservation and protection and extending of shelf life based on natural components, establishes even further Frutarom’s portfolio of solutions in this field which has been significantly strengthened following its acquisitions earlier this year of Vitiva and Ingrenat which are also active in this growing field. Active antioxidant
ingredients constitute an important supporting product for food manufacturers, and Frutarom will integrate these specialty ingredients into the comprehensive portfolio of products and solutions offered to its many customers in the savory field as well. Frutarom will work towards capitalizing on the many cross-selling opportunities arising from the acquisition and supporting the continued rapid development and production of natural functional solutions that combine taste and health in response to consumer demand and the major trends in the global food market towards more natural and healthier foods. This field is growing by leaps and bounds, and Frutarom’s unique capabilities give it a competitive edge.

Nutrafur has an R&D and sales center and an efficient manufacturing site in Murcia, Spain with large production capacity and the possibility for considerable expansion. The company has 67
employees, of which about 10 are engaged in R&D and have advanced academic degrees and expertise in various fields.

Nutrafur’s production site is in close proximity to that of Ingrenat which was acquired during the first quarter this year, and this geographic proximity between the sites will provide maximum
operational flexibility in terms of the use of various extraction technologies as well as use of the various manufacturing systems within the framework of optimizing Frutarom’s global supply
chain. The acquisition will allow for significant operational savings in Frutarom’s global manufacturing structure in the area of natural extracts and in the fields of purchasing, production, logistics, and marketing of the Company’s solutions in these fields.

Ori Yehudai, President and CEO of Frutarom Group, said: “Over the last few months Frutarom has made a major leap forward in strengthening its position as a leading global producer of natural specialty ingredients and the acquisition of Nutrafur fits in well with our rapid and profitable growth strategy while deepening and expanding Frutarom’s activity in the growing field of natural plant extracts and antioxidants for food products. We will continue investing in considerably expanding our global activity in this important and growing field both by means of strategic acquisitions and through collaboration with universities, research institutes and innovative product development startup companies.

“The Nutrafur acquisition affords Frutarom advanced R&D capabilities along with a top-level and experienced managerial team, as well as substantial customers. The acquisition provides an opportunity for improving the Group’s operational flexibility and efficiency. Thanks to Frutarom’s proven experience in the successful execution of acquisitions and realization of the many synergetic and cross-selling opportunities inherent in combining acquired activities with those of Frutarom, we are convinced that this acquisition too will contribute towards the continuation of Frutarom’s rapid and profitable growth and will generate top value for our customers, our employees, and our investors.”

Mr. Yehudai concluded by saying: “The acquisition of Nutrafur is our tenth acquisition since the beginning of the year and we are working on identifying and executing further strategic
acquisitions. We will continue implementing our rapid growth strategy which is based on combining profitable internal growth with strategic acquisitions in order to achieve the goals we
recently set for ourselves: sales reaching at least US$ 1.5 billion with an EBITDA margin of over 22% for our core activities by the year 2020.”

About Frutarom
Frutarom (LSE: FRUT, TASE: FRUT) is a multinational company operating in the global flavors and fine ingredients markets. Frutarom has significant production and development centers on all six continents and markets and sells more than 43,000 products to over 19,000 customers in more than 150 countries. Frutarom’s products are intended mainly for the food and beverages, flavor and fragrance extracts, pharmaceutical, nutraceutical, health food, functional food, food additives and cosmetics industries.

Frutarom, which employs approximately 3,500 people worldwide, has 2 main core activities:
– The Flavors Activity which develops, produces and markets flavor compounds and food systems.
– The Specialty Fine Ingredients Activity, which develops, produces and markets natural flavor extracts, natural functional food ingredients, natural pharma/nutraceutical extracts, natural food colors, natural algae based biotechnical products, natural antioxidants used in natural food protection systems, aroma compounds, essential oils, unique citrus products, natural gums and resins. The Specialty Fine Ingredients products are sold primarily to the food and beverages, flavor and fragrance, pharmaceutical/nutraceutical, cosmetics and personal care industries.

Frutarom’s products are produced at its plants in the US, Canada, the UK, Switzerland, Germany, Spain, Italy, Slovenia, Russia, Turkey, Israel, South Africa, China, India, Guatemala, Peru, Chile, Brazil and New Zealand. The Company’s global marketing organization encompasses branches in Israel, the US, Canada, the UK, Switzerland, Germany, Slovenia, Belgium, the Netherlands, Denmark, France, Italy, Spain, Hungary, Romania, Russia, the Ukraine, Poland, Kazakhstan, Belarus, Turkey, Brazil, Mexico, Guatemala, Costa Rica, Peru, Chile, South Africa, China, Japan, Hong Kong, India, Indonesia and New Zealand. The Company also works through local agents and distributors throughout the world.

For further information, please visit our website at: www.frutarom.com.

Augments Sabinsa’s Existing Canadian Master Files and 13 Natural Product Numbers

Sabinsa Corporation has received a Foreign Site Registration Number for its Payson, Utah finished product manufacturing facility from Health Canada’s Natural and Non Prescription Health Product Directorate (NNHPD). This Sabinsa manufacturing plant was recently assessed by NHPD for Natural Health Product’s GMP standards and quality system and was deemed as compliant for manufacturing health products. Foreign Sire Reference Number 5000311 allows Sabinsa to manufacture Natural Health Products for the Canadian market in the Utah facility. The Utah facility is also NSF certified.

Sabinsa Corporation already had multiple Masterfiles and Natural Product Numbers (NPN) approved for use in Canada, which allows several of its extracts in the form of finished products in the Canadian market. LactoSpore®, BioPerine®, Curcumin C3 Complex®, Curcumin C3 Reduct® and ForsLean®, among Sabinsa’s proprietary products, are available for Letter of Access requests. The most recent NPN obtained by Sabinsa is for their room temperature stable probiotic, LactoSpore® MTCC 5856.

“Availability of the NPNs with Sabinsa’s original, science-backed ingredients and the Foreign Site license for our Utah facility will greatly benefit our customers by considerably reducing the time required for product launches in the Canadian market,” said Shaheen Majeed, Marketing Director, Sabinsa Corp. “As a global company, working with regulatory agencies in an array of countries has become customary for us, but it is always rewarding to achieve another milestone like this one.”

About Sabinsa Corporation
Sabinsa‘s mission is to provide alternative and complementary natural products for human nutrition and well-­‐being. Over the past 26 years, Sabinsa has brought to market more than 100 standardized botanical extracts and privately funded several clinical studies in conjunction with prestigious institutions in support of these products. With more than 110 full time scientists conducting ongoing research in India and the United States, Sabinsa continues to develop and patent phytonutrients for the world market. All products intended for human consumption are certified Kosher and Halal. For more information visit, www.sabinsa.com.