Exotic Incan Berry Ingredient to boost Health and Taste

Frutarom BU Health, Switzerland, launches its new superberry ingredient, Incaberrix™. The water-soluble extract, rich in phytonutrients, is prepared from the ancient Andean physalis fruit (Physalis peruviana), also known as Inca berry, cape gooseberry or golden berry.

Inca berry is considered one of the “lost” crops of the Incans. It is native to the Andes, where it has been cultivated since ancient times. Many traditional Andean foods have an historic association with improved health and longevity. Maca and quinoa are examples of Andean staple crops rich in phytonutrients that became recognized as “super foods” in recent years.

“Now is the time for Inca golden berries,” states Yannick Capelle, Product Manager for Frutarom Health. “The concentrated nutrient value adds health benefits, combined with fun and an exotic touch, to a wide range of food applications. But the sweet and tart berry’s primary category is beverages, including soft drinks, nutritional beverages and more. We strive to lead in market innovation by developing such natural ingredients that can both lead food and beverage trends and support health.”

Incaberrix is particularly rich in B-complex vitamins, protein and minerals such as iron, zinc and phosphorus. It also is high in vitamin C and carotenoids. Recent tests in Frutarom Innovation Center show that clear, water-soluble Incaberrix is stable in beverage applications.

“Superberry ingredients such as Incaberrix are attractive ingredients for product developers and manufacturers seeking to add value to their food and beverage products,” notes Capelle. ”The introduction of this new superberry extract by Frutarom is part of the company’s ongoing strategy to comprehensively serve the functional product market through our group synergies and goals. Incaberrix is another example of how Frutarom combines its strength in developing exotic flavors with healthy ingredients to offer its clients innovative, great-tasting product concepts,” concludes Capelle.

About Frutarom
Frutarom is a leading flavor and fine ingredients house ranked among the top 10 companies in the global market. Fulfilling its commitment to become the preferred partner for taste-driven, healthy success, Frutarom provides advanced solutions for the food & beverage, nutraceutical, pharmaceutical and cosmetic industries.

Vitamin B5 Derivative Combined with Artichoke for Cholesterol Management*

New York City,  – Life Extension® is offering a new cholesterol-management supplement called Chol-Support™ that utilizes Pantesin® Pantethine and an artichoke extract.

Chol-Support™ contains a 300 mg dose of Pantesin® Pantethine – a branded form of a Vitamin B5 derivative that has been shown to promote already healthy levels of LDL and non-HDL cholesterol levels while increasing valuable CoQ10 stores, as published in a study published in Vascular Health and Risk Management.* It’s combined with 250mg of Pycrinil® artichoke extract from the plant’s leaves.

For more information about the study, visit:
http://www.dovepress.com/pantethine-a-derivative-of-vitamin-b5-favorably-alters-total-ldl-and-n-peer-reviewed-article-VHRM.

About Life Extension
For more than 35 years, Life Extension® has been a pioneer in funding and reporting the latest anti-aging research and integrative health therapies while offering superior-quality dietary supplements to consumers.
Life Extension has a long history of offering prescient health guidance to American consumers, in many cases years ahead of the mainstream medical establishment. For example, in 1983, Life Extension recognized the value of daily low-dose aspirin to reduce the risk of vascular problems, years before the practice enjoyed widespread acceptance. For more information, visit www.lifeextension.com.

About Pantesin® Pantethine
Pantesin® is a high-quality, pharmaceutical grade branded form of Pantethine, a derivative of vitamin B-5. Supplied worldwide by Daiichi Fine Chemical Co., Ltd, a subsidiary of Kyowa Hakko Bio Co. Ltd. (Kyowa Hakko Bio), and distributed by Kyowa Hakko U.S.A., the ingredient Pantesin® can be found in many dietary supplements designed to support heart health. Pantesin® has been well-researched for over 35 years, including human clinical studies in both Asian and North American countries, and has been shown to provide vital cardiovascular health benefits. For more information, visit www.pantesin.com.
*Pantesin® is a registered trademark of Daiichi Fine Chemical Co., Ltd.

About Kyowa Hakko USA
Kyowa Hakko USA is the North American sales office for Kyowa Hakko Bio, an international health ingredients manufacturer and world leader in the development, manufacturing and marketing of pharmaceuticals, nutraceuticals and food products. Kyowa Hakko Bio is the maker of branded ingredients including Cognizin® Citicoline, Pantesin® Pantethine, Setria® Glutathione, as well as Sustamine® L-Alanyl-L-Glutamine. For more information, visit http://www.kyowa-usa.com.

Fytexia gets Canadian approval for flagship weight management and antioxidant ingredients

French-based polyphenol specialist Fytexia has obtained Natural Product Numbers (NPN) from the Canadian Natural Health Product Directorate (NHPD) for the ingredients Sinetrol and Oxxynea, along with accepted claims recognizing their health benefits.

The successful registration of the company’s two best-selling materials validates Fytexia’s decision to enter the Canadian market. In addition to unlocking appealing sales opportunities, the NHPD’s approval provides new recognition of the strong body of research supporting Sinetrol and Oxxynea, thereby adding momentum to the current growth of these ingredients worldwide.

Obtained in collaboration with the Canadian-based consultancy Quality Smart Solutions, both Product Licenses have validated strong claims about the ingredients’ properties. Sinetrol was particularly accepted as an ingredient for weight management support based on two published clinical studies from Fytexia. In addition to showing Sinetrol’s significant impact on body fat loss, this research also highlighted a reduction of oxidative stress, allowing the NHPD to approve an additional label claim about this benefit.

In the antioxidant segment, Fytexia’s goal is to respond to the Canadian demand for natural, whole-food materials with Oxxynea, a blend of 22 fruit and vegetables which antioxidant properties were recognized by Health Canada. In recent research, Fytexia found that a daily dose of this blend provided antioxidant benefits equivalent to five servings of fruit and vegetables.

For more details, please contact Fytexia at contact@fytexia.com

NEW BRUNSWICK, N.J. – CAPROS® from Natreon gets a U.S.Patent (8,962,576) for endothelial function improvement, a publication of another clinical study from Ohio State University Medical Center on its cardiovascular benefits in the Journal of Medicinal Food and a “No Questions” GRAS letter from FDA.

U.S.Patent 8,962,576 – The claims in this patent cover endothelial function improvement, increase in production of nitric oxide and lipid levels by an extract of Phyllanthus emblica. This patent is based on the clinical data in type 2 diabetics as well as pre-diabetic subjects.

Clinical Study Publication – “Supplementation of a Standardized Extract from Phyllanthus emblica Improves Cardiovascular Risk Factors and Platelet Aggregation in Overweight/Class-1 Obese Adults

J Med Food 18 (4) 2015, 415–420
http://online.liebertpub.com/doi/pdf/10.1089/jmf.2014.0178

The objective of this study (clinicaltrials.gov NCT01858376) was to determine the effect of oral supplementation of CAPROS® on cardiovascular disease (CVD) risk factors in overweight adult human subjects from the US population. Overweight/Class-1 obese (body–mass index: 25–35) adult subjects received 500 mg of CAPROS® supplement b.i.d for 12 weeks. The study design included two baseline visits followed by 12 weeks of supplementation and then 2 weeks of washout. At all visits, peripheral venous blood was collected in sodium citrate tubes. Lipid profile measurements demonstrated a significant decrease in calculated low-density lipoprotein cholesterol and total cholesterol/high-density lipoprotein following 12 weeks of CAPROS® supplementation when compared to averaged baseline visits. Circulatory high-sensitivity C reactive protein (hs-CRP) levels were significantly decreased after 12 weeks of supplementation. In addition, both ADP- and collagen-induced platelet aggregation was significantly down-regulated following 12 weeks of supplementation. Overall, the study suggests that oral CAPROS® supplementation may provide beneficial effects in overweight/Class-1 obese adults by lowering multiple global CVD risk factors.

GRAS Status – FDA has sent a “No Questions” letter to Natreon for the use of Capros in non-alcoholic beverages, processed fruits and fruit juices, and cereals at levels up to 150 milligrams per serving. Natreon estimated mean and 90th percentile intakes of Capros® to be 445 and 868 mg/person/day, which corresponds to 7.7 and 14.5 mg/kg body weight/day respectively. Natreon also has a self-affirmed GRAS status for Capros®.

Dr. Sanni Raju, CEO of Natreon, says that Capros®, backed by a total of nine clinical studies and an ischemia-reperfusion study from University of Connecticut Medical Center, is the next generation cardiovascular supplement, as it offers much more comprehensive heart health benefits than the current heart health products in the market at a lower dose. Capros® is suitable for solid dosage forms as well as solutions since it is water-soluble and stable with neutral taste and flavor.

For more information, visit Natreon at www.natreoninc.com or contact:

Sanni Raju, Ph.D., R.Ph
sanni@natreoninc.com
Tel: +1 732-296-1080
Cell: +1 908-239-6955

Oral Supplementation with a Combination of Kyowa Hakko’s L-Citrulline and L-Arginine Can Rapidly Increase Nitric Oxide Bioavailability

Study Shows Promise in Human Applications for Regulating Cardio Function*

New York City, NY (PRWEB)  – A combination of L-Citrulline and L-Arginine oral supplementation caused a more rapid increase in plasma L-Arginine levels and marked enhancement of Nitric Oxide bioavailability, including plasma cGMP (Cyclic guanosine monophosphate) concentrations, than with dosage with the single amino acids.

The study, published in Biochemical and Biophysical Research Communications, set out to determine the short-term action of oral doses of L-Citrulline and L-Arginine on nitric oxide production. Results showed that the combined supplementation was significantly more effective than single doses of arginine.1

For more information about the BBRC-published study, visit http://www.sciencedirect.com/science/article/pii/S0006291X14018178.

1) Masahiko Morita, Toshio Hayashi, Masayuki Ochiai, Morihiko Maeda, Tomoe Yamaguchi, Koichiro Ina, Masafumi Kuzuya, Oral supplementation with a combination of l-citrulline and l-arginine rapidly increases plasma l-arginine concentration and enhances NO bioavailability, Biochemical and Biophysical Research Communications, Volume 454, Issue 1, 7 November 2014, Pages 53-57, ISSN 0006-291X, http://dx.doi.org/10.1016/j.bbrc.2014.10.029.

About Kyowa Hakko’s L-Citrulline
L-Citrulline is an amino acid that plays an important role in nitric oxide metabolism and regulation. L-Citrulline is converted to L-Arginine in the body, leading to sustained increases in both L-Arginine and nitric oxide. An ingredient with application in the areas of heart health and sports nutrition, L-Citrulline is preservative-free, allergen-free, and contains no artificial flavors or colors. It’s non-hygroscopic, highly stable, and mild taste makes it suitable for use in a variety of formulations. This pure, vegetarian ingredient is also self-affirmed GRAS. Manufactured in the U.S. using a proprietary fermentation process, L-Citrulline is an ultra-pure amino acid that carries the Kyowa Quality logo, ensuring the ingredient is backed by our commitment to the highest manufacturing standards.

About Kyowa Hakko USA
Kyowa Hakko USA is the North American sales office for Kyowa Hakko Bio Co. Ltd. (Kyowa Hakko Bio), an international health ingredients manufacturer and world leader in the development, manufacturing and marketing of pharmaceuticals, nutraceuticals and food products. Kyowa Hakko Bio is the maker of branded ingredients including Cognizin® Citicoline, Lumistor® L-Hydroxyproline, Pantesin® Pantethine, Setria® Glutathione, as well as Sustamine® L-Alanyl-L-Glutamine. For more information visit www.kyowa-usa.com.

St. Charles, MO USA – Stratum Nutrition announces that new research demonstrating the clinical benefit of ACTAZIN™, a green kiwifruit ingredient produced by Anagenix, Ltd for digestive health, has recently been published in the journal Nutrition Research (DOI: http://dx.doi.org/10.1016/j.nutres.2015.04.005).

This randomized, double-blind, placebo-controlled study displayed clinically significant benefits in a healthy cohort.

Gastrointestinal issues, including constipation, are common conditions worldwide in adults and children, which can severely affect the individual’s quality of life and feeling of general wellbeing. Gastrointestinal issues are regarded by many clinicians to be an underlying cause of a variety of illnesses.

The study evaluated 19 healthy adult volunteers and 9 volunteers with complaints of functional constipation for stool frequency and quality along with a daily diary for quality of life. The results of this clinical trial demonstrated a statistically significant increase (P < 0.014) in mean daily bowel movements (healthy cohort) following one month of ACTAZIN (2400 mg/day) consumption. The magnitude of effect corresponded to an approximate increase of 1 bowel movement per week, which is regarded as a clinically meaningful effect by the FDA. A lower daily dose of ACTAZIN (600 mg) produced a numerically equivalent result, just missing statistical significance (P < 0.06) across the entire group, but was statistically significant in the responder sub-group (P < 0.005; n = 14). This suggests that a low dose (600 mg) of ACTAZIN alone could help maintain a healthy digestive system.

ACTAZIN is a powdered ingredient derived from whole New Zealand green (Actinidia deliciosa ‘Hayward’) kiwifruit from which the skin and seeds are removed and the remaining flesh cold processed for use in dietary supplements for the support of digestive health. Contributing to the modes of action for ACTAZIN include the presence of bioactive substances including fiber, polyphenolics, and the kiwifruit-specific enzyme, actinidin. An additional mode of action of ACTAZIN is possibly due to its ability to serve as a substrate for endogenous gut bacteria. For more information on ACTAZIN, please visit www.StratumNutrition.com

Videos with clinical principles explaining findings and significance available:
https://www.youtube.com/playlist?list=PLI284lYQohMIAoN3K_EXhWwkdLed8Nrva

About Stratum Nutrition
Stratum Nutrition, a Novus International company, is a specialty health ingredient supplier to the supplement and pet food industries. Stratum offers a portfolio of branded, value-added ingredients developed in collaboration with global partnerships such as Anagenix, based on consumer need, and supported by science. Stratum specializes in condition-specific categories which include digestive, immune, and structural health to offer full solutions for human and companion animal nutrition. Leveraging the Novus core competencies in nutritional research and innovation, these ingredients are innovative, safe, and substantiated by clinical research. www.StratumNutrition.com

Reference
Ansell J et al (2015). Kiwifruit derived supplements increase stool frequency in healthy adults: a randomized, double-blind, placebo-controlled study. Nutrition Research. DOI information: 10.1016/j.nutres.2015.04.005

Get Ready for Increased Concentration and Optimal Focus*

New York City,  – Cerebral Success has combined the power of Cognizin® Citicoline with other brain health ingredients to create SmartX™ for increased mental energy and focus.*

SmartX™ – which received financial backing from the TV show Shark Tank – helps increase mental energy and overall alertness while supporting other brain functions as well. Cognizin® Citicoline is a major part of the detailed chemical composition of SmartX™ allows it to simultaneously influence four areas of brain power: focus, memory, mental energy, and overall brain health.*

It is now easier to obtain SmartX as they have expanded their distribution to GNC stores, Amazon.com and eSupplements.com, luckyvitamin.com and more are lined up.

Cognizin® Citicoline is a branded form of citicoline, an essential substance for brain health. It works to enhance communication between neurons, maintain normal levels of acetylcholine, protect neural structures, and enhance health brain activity and energy.  For more information about Cerebral Success SmartX™, visit www.cerebralsuccess.com.

About Cerebral Success
Cerebral Success is a brain-health company based out of Provo, Utah, that has developed a safe brain supplement that supports focus, memory, mental energy, and overall brain health.

Trevor Hiltbrand, Cerebral Success founder/CEO has steadily gained attention from students and individuals in the work force looking for a healthy way to enhance their focus, memory and health. In April 2014 Cerebral Success was featured on ABC’s Shark Tank, and was successful in winning an investment from Barbara Corcoran. Through the last three years Cerebral Success has perfected and modified its featured product to develop the best brain supplement yet: SmartX.

About Cognizin® Citicoline
Cognizin® is a branded form of Citicoline, a natural substance found in every cell of the body and especially vital to brain health.* Citicoline is broken down during intestinal absorption and, after passing through the blood/brain barrier, is reconstituted in the brain as citicoline.* Citicoline is a water-soluble compound that supplies precursors for the synthesis of phospholipids, including phosphatidyl-choline, a major constituent of brain tissue*; helps maintain normal levels of acetylcholine, a chemical that regulates memory and cognitive function*; enhances communication between neurons*; supports visual function*; protects neural structures from free radical damage*; enhances metabolism and healthy brain activity*; and helps sustain healthy cellular mitochondria for sustained energy*. Cognizin® is also highly stable, GRAS, ultra-pure and allergen-free. For more information on Cognizin ®, visit www.cognizin.com.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

About Kyowa Hakko USA
Kyowa Hakko USA is the North American sales office for Kyowa Hakko Bio Co. Ltd. (Kyowa Hakko Bio), an international health ingredients manufacturer and world leader in the development, manufacturing and marketing of pharmaceuticals, nutraceuticals and food products. Kyowa Hakko Bio is the maker of branded ingredients including Cognizin® Citicoline, Lumistor® L-Hydroxyproline, Pantesin® Pantethine, Setria® Glutathione, as well as Sustamine® L-Alanyl-L-Glutamine. For more information visit www.kyowa-usa.com.

Fytexia releases new scientific publication on the benefits of Sinetrol for body fat loss and preservation of muscle mass in male subjects, opening more product positioning opportunities.

As worldwide consumer demand shifts more and more toward personalized nutrition, the company collected and published new human data in order to address the specific needs of men. Fytexia’s Director of Research and Innovation, Dr Julien Cases, pointed out the importance of understanding the differences between genders when looking for ways to improve body composition. As widely accepted by the scientific community, men and women don’t have the same metabolism, particularly when it comes to fat storage in adipose tissues.

From a marketing standpoint, they also are two very different groups of consumers with different goals. In the fat burning segment, one can easily observe that men-oriented products usually put more emphasis on muscle mass maintenance or development than women’s formulas.

With these distinctions in mind, Fytexia reports the results from a 12-week study conducted on 25 men (13 in the placebo group and 12 in the Sinetrol group). All subjects followed the same normo-caloric diet standardized between 2200 and 2500kcal per day and were instructed to exercise 30 min per week. Subjects in the Sinetrol Xpur group took two capsules of 450mg of the active ingredient every day, while the other group took the same quantity of a placebo.

After 4 weeks, significant differences between the two groups were already observed on waist and hip size reduction, and on weight loss after 8 weeks. At the end of the 12-week period, results showed Sinetrol Xpur had a significant impact on all key parameters:

• Abdominal fat: -9.7 % with Sinetrol Xpur vs -4.8 % with the placebo (p<0.001)
• Waist size reduction: -7.4 cm with Sinetrol Xpur vs -2.1 cm with the placebo (p<0.001)
• Hip size reduction: : -5.6 cm with Sinetrol Xpur vs 2.0 cm with the placebo (p<0,001)
• Waist-to-hip ratio: -2.27% with Sinetrol Xpur vs 0.20% with the placebo (p<0.05)

Other parameters showed that losing fat did not mean losing muscle. Typical signs of skeletal muscle mass reduction is a higher urinary excretion of creatinine, higher inflammation and higher oxidative stress. In this study, creatinine excretion stayed at the same level in the Sinetrol group, while placebo subjects saw their level increase. Sinetrol was also able to significantly decrease inflammation markers (CRP, fibrinogen) and MDA – a marker of oxidative stress.

This third article completes two previously published clinical studies on a total of 115 subjects.

By combining these publications, Fytexia’s goal is to provide reliable scientific material for the development of men-oriented fat loss formulas. The company will be presenting complete details about the new publication at Vitafoods Europe in May.

For more details, please contact Fytexia at contact@fytexia.com

In this newsletter we have highlighted 8 Metabolism boosting Ingredients.

Read the Metabolism special HERE

More branded ingredients can be found online in the Metabolism category.

Sabinsa launches new, nano-free water soluble Curcumin: uC3 CLEAR

East Windsor, NJ – Sabinsa Corporation has introduced a new form of Curcumin which is completely water soluble, a major breakthrough in Curcumin technology: uC3 CLEAR™

“Curcumin health drinks are very popular in countries like Japan, which consume it for managing joint health, liver health, antioxidant/oxidative stress, and even hangovers,” said Anurag Pande PhD, Sabinsa VP Scientific Affairs. “However poor curcumin solubility and resulting sedimentation in these beverage make it visually unappealing. While nano technology has been able to overcome some of the limitations, many people just aren’t comfortable ingesting nanos. Our R&D scientists have created uC3 CLEAR to make curcumin visually appealing without adding a science fictional element to it.”

uC3 CLEAR not only provides an improved, more convenient delivery system for Curcumin but also overcomes the challenges and limitations that can be present with solid dosage delivery systems such as poor disintegration, slow dissolution, or difficulty swallowing, thus enhancing the uptake of curcumin. The GRAS status of Curcumin C3 Complex extends to uC3 CLEAR.

Sabinsa’s expertise with Curcumin innovation is indisputable, with Curcumin C3 Reduct® solving the problem of staining, and C3 Complex®, the most clinically researched Curcumin in the world.

Samples and availability of uC3 CLEAR will begin in April.

About Sabinsa Corporation
Sabinsa‘s mission is to provide alternative and complementary natural products for human nutrition and well-­‐being. Over the past 26 years, Sabinsa has brought to market more than 100 standardized botanical extracts and privately funded several clinical studies in conjunction with prestigious institutions in support of these products. With more than 110 full time scientists conducting ongoing research in India and the United States, Sabinsa continues to develop and patent phytonutrients for the world market. All products intended for human consumption are certified Kosher and Halal. For more information visit, www.sabinsa.com.