The newly issue of the Gnosis’ vitaMagazine has been just released and focuses on the close relationship between the vitamin K2 as MK7 derived from the natural fermentation of the bacteria Bacillus subtilis natto, and its efficacy, stability and safety.
The discovery of natto – traditional Japanese food with the highest content of MK7 and obtained from soybeans fermentation – gave Gnosis the basis to produce, almost 20 years ago, a real natural, pure, stable and safe vitamin K2 as MK7, with the brand name of VitaMK7®.
The microbial strain of the B. subtilis natto – highly purified and grown under certain natural conditions by Gnosis – is able to guarantee the highest purity (all-trans active isomer > 99%) and the total absence of unknown impurities, providing an extraordinarily pure and natural product, with a highly safe profile.
Furthermore, thanks to its clean profile, VitaMK7® minimizes cross-reactions with other ingredients, and ensures greater effectiveness and stability in formulations!
Up today, all human clinical trials published, that support the benefits in the bone and the cardiovascular health, have been performed with vitamin K2 as MK7 from Bacillus subtilis natto.
To require a pdf copy visit Gnosis website http://www.gnosis-bio.com/news.php?p=52
The leaflet will be disclosed during next Vitafoods edition. Visit Gnosis Booth #I140

A unique, science-supported blend to help maximize strength training benefits to give athletes the competitive edge they are looking for.

Kyowa Hakko will host a special session titled “Setria® Performance Blend – A New Dietary Approach to Enhance and Sustain Nitric Oxide Availability” to introduce and discuss the benefits of its latest patent-pending blend targeting athletes and sports enthusiasts at Vitafoods™ Europe on May16th in Geneva, Switzerland.

Setria® Performance Blend is a novel combination of Kyowa Hakko’s own Setria Glutathione and L-Citrulline. The blend is designed to help athletes maximize muscle output and achieve better strength-training results, while reducing fatigue and speeding muscle recovery.

The 30-minute session will be held May 16th at 11:40 a.m. GMT/UTC+2 in the Sports Nutrition Zone Theater at the Palexpo Convention Centre and will be presented by Karen E. Todd, Kyowa Hakko U.S.A. director of global brand marketing.
The presentation will focus on benefits and challenges of Nitric Oxide support during exercise, the vital role of glutathione in helping to sustain the biological effects of NO and its antioxidative properties during intense exercise. Attendees will also learn the latest science behind Setria® Performance Blend.

At Vitafoods Kyowa Hakko, a manufacturer of Setria® Performance Blend, will also showcase a variety of its innovative branded ingredients for healthy aging and sports.
About Karen E. Todd

Karen E. Todd is a Registered Dietitian, Certified Strength and Conditioning Specialist and Health & Fitness Specialist with more than 25 years’ experience in exercise performance and nutritional product development and education. Currently, she is the Sr. Director of Global Brand Marketing for Kyowa Hakko U.S.A.
About Vitafoods Europe

Vitafoods Europe is the global nutraceutical event, featuring exhibitors from all over the world in four key market areas: ingredients & raw materials; branded finished products; contract manufacturing & private label; and services & equipment. The event offers a range of visitor attractions, including an industry-leading education programme.
Vitafoods Europe is part of Informa Exhibitions’ Global Health & Nutrition Network (GHNN), which brings together a portfolio of events, digital media and publishing for marketers, manufacturers and formulators of nutrition and dietary supplements, healthy foods/beverages and personal care products. GHNN’s events include Vitafoods Europe, Vitafoods Asia, SupplySide West and Ingredient Marketplace.

Rimouski (Quebec), April 16, 2018 – innoVactiv is pleased to announce that Blake Jorgensen has joined innoVactiv as Director of Sales – North America effective immediately. Blake will be based in the Salt Lake City area.

Prior to joining innoVactiv, Blake has developed extensive experience in the dietary supplements and cosmetic industries, having spent 10 years within various companies such as United 1 International Laboratories, Bifodan, Capstone Nutrition and Nutraceutical Corp.

“We are delighted to welcome Blake to innoVactiv. Blake has a proven track record demonstrating his capacity to effectively manage sales and customer relationships as well as in-depth knowledge of the U.S. dietary supplement industry. He will represent a great asset as we grow our customers base in the U.S. with our specialty ingredients portfolio”, said Bernard Couture, Vice-President Sales & Marketing of innoVactiv.

Gnosis is glad to inform that Adonat® WhitePaper, which is dedicated to the Gnosis commercially stable form of S-Adenosyl-L-methionine (SAMe), has been recently implemented with new contents and with updated results from the latest clinical studies.

The great importance of the One Carbon Metabolism, crucial for people overall health and well-being, has always led researchers to be particularly interested in discovering how the availability and levels of molecules involved into this metabolic pathway can influence and affect human health, with particular emphasis on SAMe, the most important human methyl donor, capable to sustain the above cycle activity.

Adonat® is involved in more than one hundred biochemical pathways and is important for a variety of functions including detoxification, energy production, immune function, gene maintenance and regulation, mood balancing and inflammation control.

In the new Adonat® WhitePaper, besides the well-known and most studied fields of application of SAMe ranging from the mood enhancement to the liver protection and detoxification, new clinical evidence suggests its wider involvement in preventing aging and supporting cell and organ longevity, including also brain as well as sexual functions and cellular metabolism.

Gnosis has been the first to introduce and commercialize SAMe in the worldwide market and, with over 30 years of experience, today is considered the global leader in SAMe manufacturing from a selected highly productive yeast using fermentation technologies, under the brand name of Adonat®, with a complete range of bulk powder, enteric coated tablets and stabilized oral dosage forms for pharmaceutical, nutritional and veterinary applications.

Adonat® has excellent features:

– it is one of the most studied and proven effective nutritional compounds produced by Gnosis to support mood, joint, liver health, anti-aging and longevity

– it has  a superior quality with the highest content of the biological active form, the (S,S) active diastereoisomer and the longest available shelf-life in the market.

Cognitive impairment is a substantial public health concern due to the exponentially increasing number of older adults. Developing novel strategies to protect cognition in the elderly population is critical for managing the disease burden and cost of care. Large range of variables that will dictate the extent to which humankind develops neuropathologies as cognitive impairment. Processes related to cognitive decline/dementia begin to damage the brain many years, if not decades, before symptoms become apparent and cause a progressive decline in functioning as more of the brain is damaged, making early intervention key to slowing/preventing cognitive decline.

Folate, such as the metabolic active form Quatrefolic® is among the nutrients with potential significance for retention of cognitive capabilities and prevention of cognitive decline in old age. Clinical research states that a daily supplementation with folate helps improving cognitive performances, including memory and information processing.

Folate plays important roles in t the synthesis of DNA, gene expression, homocysteine (Hcy) detoxification and synthesis of neurotransmitters necessary for the maintenance of cognitive function, through the participation in the one-carbon metabolism, the life-sustaining pathways that happens in each cell of the body.

In particular, the 5-methyltetrahydrofolate (5-MTHF or L-methylfolate), such as Quatrefolic®, is the only form of folate able to enter the brain without previous metabolism. Quatrefolic® passes the Brain Blood Barrier (BBB) and can support brain function in subject with reduced metabolism of folate, due to a genetic defects (polymorphisms) of a key enzyme 5-methylentetrahydrofolate reductase (MTHFR), which impair the folate conversion and the body ability to produce 5-MTHF.

However, the effective intake of folate plays a significant role, as folic acid is not biologically active and must be metabolized in order to be absorbed. As a result, for those individuals with MTHFR polymorphism, folate may be difficult to assimilate.

“A new edition of the Gnosis magazine “News from Science” with the title of “Folate and Cognitive Impairment: the Protection of Memory” has been just issued. The leaflet helps to understand the role of folate in cognitive”, said Lorena Carboni, Products Supports Specialist of Gnosis. “It highlights why Quatrefolic® is kindly recommended to those individuals who, due to their unique genetic patterns and expression, own MTHFR enzyme polymorphism and do not produce adequate or effective Methylentetrahydrofolate reductase (MTHFR), thus encountering all health problems associated with the lack of vitamin B9.”

The leaflet is available at following link Quatrefolic and the protection of memory

March 14, 2018 New York, NY

Expert discusses novel ingredient combination at Nutrition Summit

Setria® Performance Blend – a novel combination of L-citrulline and glutathione – may enhance the synthesis, bioavailability, and bio-efficacy of nitric oxide for athletes.*

That’s the message Stephen Bailey, Ph.D., gave to attendees at last week’s Nutrition in Athlete Development Summit in Madrid. Dr. Bailey was one of several experts who discussed best practices and latest innovative approaches in sports nutrition for professional athletes, coaches, sport club officials, and producers of sports nutrition and supplements.*

Studies have shown that Kyowa’s Setria® Performance Blend supports nitric oxide production and sustains nitric oxide levels in the bloodstream. In addition Setria® Glutathione, which is the body’s most important antioxidant, allows for longer workouts by increasing time to fatigue while protecting muscle cells from free radicals and oxidants*

In his presentation, Dr. Bailey showed that increasing NO has a positive impact on several biological functions that extend well beyond vasodilation, such as skeletal muscle metabolism and force production during exercise.

“Oral L-citrulline supplementation is more effective than the same dose of orally ingested L-arginine at increasing circulating and tissue L-arginine content,” Dr. Bailey said. “Adding GSH [in the form of Setria® Performance Blend] as a non-enzymatic antioxidant to help neutralize reactive oxygen species (ROS) may sustain the biological effects of NO.*

Setria® Performance Blend is manufactured by Kyowa Hakko Bio, a sponsor of the Nutrition in Athlete Development Summit.

About Stephen Bailey, PhD

Dr. Bailey is a lecturer in Sport & Exercise Nutrition at Loughborough University in the United Kingdom. He completed his PhD at the University of Exeter with his PhD research

recognised through awards of 1st position in the 2010 European Colleague of

Sport Science Young Investigator Award and the Tom Reilly Doctoral Dissertation

of the Year Award from the British Association of Sport and Exercise Sciences in 2011. He was appointed as a lecturer in exercise physiology at the University of Exeter before taking up his current role as a lecturer in sport and exercise nutrition at Loughborough University in 2016.

Dr. Bailey’s principal area of interest and expertise surrounds nutritional interventions to enhance the synthesis and bioavailability of the multi-functional physiological signaling molecule, nitric oxide, and the impact of such interventions on cardiovascular health and exercise performance. He also has broader interests in oxidative metabolism and skeletal muscle fatigue. Dr. Bailey has published over 60 original research articles on these topics as well as several invited review articles and book chapters. He has delivered invited presentations at a number of international conferences and is currently on the journal editorial boards for Scientific Reports, BMC Sports Sciences, Medicine & Rehabilitation and Frontiers in Sport and Exercise Nutrition.

About Setria® Performance Blend

Setria® Performance Blend is a new, branded, patent-pending blend of L-citrulline and Setria® glutathione – Kyowa’s Setria® Performance Blend. Studies have shown that this blend supports nitric oxide production and sustains nitric oxide levels in the bloodstream.

Setria® Performance Blend may:

Support NO levels post-workout*

Sustain NO levels post-workout*

Aid in vasodilation to help fuel muscles*

MARCH 2018 – Researchers at Central Michigan University have taken a closer look at Longvida® Optimized Curcumin. Previously, these researchers conducted amyloid binding work in vitro with promising results1-2. Recently published in the journal BMC Neuroscience, Maiti P et al compared standard, curcumin to solid lipid curcumin (Longvida).

The present study, “was designed to compare the effects of acute treatments of [65% curcumin] and/or SLCP™ [Longvida® with 20% curcumin], on anti-inflammatory activities, Aβ plaque loads, and neuronal morphology in different brain regions of 5xFAD mice.”3 This study indicates, “the low solubility in body fluids and rapid degradation after intestinal absorption limit the bioavailability of [unformulated] curcumin, reducing its clinical utility. However, the use of SLCP, a lipidated formula of curcumin, shows significant promise in providing greater neuroprotective effects. In the present study, we observed that SLCP tended to have greater affinity to Aβ plaques, compared to [unformulated] curcumin. Our findings suggest that the lipid bilayer of SLCP facilitates its permeability into the brain.”3

While it is known that many researchers have conducted both in vitro and in vivo work in both animals and humans, many studies have utilized chronic treatment to overcome the major obstacles of delivering therapeutically significant amounts due to poor solubility, instability in physiological fluids, and low bioavailability.3

In this study, Maiti and team brought to light additional research showing the benefits of acute treatment with curcumin in a murine model for either 2 (two) or 5 (five) days. This publication adds to previous research and finds Longvida® SLCP™ as a “potent, antiamyloid and anti-inflammatory natural polyphenol”.3

“Interestingly, we achieved greater anti-inflammatory effects in the case of SLCP [Longvida] treatment, which, again confirmed that the SLCP facilitates permeability of curcumin across the blood brain barrier (BBB) … to a greater degree than [unformulated] curcumin.” They go on to conclude that SLCP provided greater neuroprotective effects compared to [unformulated] curcumin in 5xFAD mice.3 “Moreover, we have compared the permeability of curcumin in different cells, such as 7-DIV primary hippocampal neurons and N2a cells and found that SLCP tended to deliver more free curcumin into the cells than did [unformulated] curcumin.”  Furthermore, the researchers note that 5-days of treatment had greater impact than 2-days in both groups, suggesting that a longer duration can better optimize the tangible health benefits seen.

“Not only is it very exciting to see these results from Maiti P et al, but it is absolutely fantastic to have additional support for our previous research efforts on Longvida,” states Kristen Marshall, Marketing Coordinator, Verdure Sciences

Sonya Cropper, VP of Innovation & Marketing at Verdure Sciences, stated “this publication highlights the potential impact Longvida (SLCP) has on various neurological measures, with valuable insight into the difference on permeability and specific activity between curcumin and solid lipid curcumin (Longvida®). The continued interest in curcumin from the research community will continue to bring a greater understanding on potential benefits, as well as the difference regarding various optimizing technologies.”

The key to the success of Longvida lies within the patented and proprietary Solid Lipid Curcumin Particle Technology, or SLCP™. This technology encapsulates the free curcumin in Longvida® in a tri-lipid matrix, allowing it to enter the bloodstream, and cross the blood brain and blood retinal barriers. †

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

We are proud to announce that our product Biootic® has successfully passed the Non-GMO Project’s Product Verification Program, designed to assess compliance with the Non-GMO Project Standard. It has been included in the product lists available at the following websites: nongmoproject.org and livingnongmo.org.

Non-GMO Project is a nonprofit organization committed to preserving and building sources of non-GMO products, educating consumers and providing verified non-GMO choices. It is the only independent verification program in North America that provides the trusted seal for non-GMO (not genetically modified organisms) food and products.

“Consumer demand for non-GMO ingredients and products is growing. We are delighted to achieve Non-GMO Project Verification for our probiotic yeast Biootic® because this label represents an additional assurance to our partners and customers about the non-GMO origin of Biootic® and demonstrates Gnosis’ continuous commitment to safety and transparency. This distinctive label is a competitive advantage for our customers because they can provide a higher level of trust to their customers, meeting US market demands to have cleaner labels” – said Silvia Pisoni, Marketing Manager of Gnosis.

Biootic® S. boulardii is a yeast probiotic with bioregulatory effect on the intestinal flora helping to maintain a normal balance of friendly bacteria in the intestine that modulates immunity. It may support gut function under many conditions, including inflammatory bowel disease, irritable bowel syndrome and traveler’s diarrhea. It is obtained through a proprietary strain and patented process of Gnosis, providing greater stability and delaying the yeast aging process, such as cell deterioration and product contamination. We have been pleased to share with you this latest favorable target achieved by Gnosis, and we invite all consumers to catch the “Butterfly label”, a guarantee for US consumers of non-genetically modified products.

Nacka (Sweden), March 2018 – AstaReal, the global pioneer and most studied brand of natural astaxanthin, will be showcasing their superior range of bulk natural astaxanthin products in addition to several finished formulations at Vitafoods 2018. Soft gums and effervescent products using AstaReal® natural astaxanthin, show the possibilities of AstaReal to address a variety of dosage forms and astaxanthin’s ability to work in various formulas. Natural astaxanthin is one of the most powerful antioxidants with scientifically backed health benefits for muscles, skin, heart, brain, eyes, digestion and the immune system. On Tuesday 15 May at 14:20, the company’s global ambassador, Dr Mark Miller, will discuss the latest research findings in his lecture on “Astaxanthin – The Ultimate Mitochondrial Nutrient for Performance & Recovery” at the Sports Nutrition Zone Theatre.

 Natural astaxanthin from the microalga Haematococcus pluvialis is a powerful antioxidant and anti-inflammatory agent. Its unique structure allows it to quench free radicals in the inner and outer layer of the cell membrane unlike other antioxidants, thus protecting lipids, proteins, DNA and mitochondria from oxidative stress. In this way, astaxanthin can boost muscle endurance and recovery, enhance fat metabolism and reduce muscle damage as well as inflammation. Studies have shown that it is also able to lower lactic acid build up and decrease fatigue. This makes it a valuable ingredient for supplements targeting the sports nutrition market.

 Andie Long, Marketing & Sales Manager at AstaReal AB, says: “As a global leader in the market, we recognize our responsibility to educate people about the benefits of natural astaxanthin for human health. We are delighted that Dr Mark Miller, who has made significant contributions as researcher, entrepreneur and marketer in the fields of health and medicine, will join us at Vitafoods. His presentation will delve into the latest science and market opportunities for natural astaxanthin and  explore its unique actions which reveal why it is becoming the premier ingredient for performance and recovery.“

AstaReal, the official natural astaxanthin sponsor for Vitafoods, can be found at booth I44 and in the fair’s Sports Nutrition Zone – an interactive demonstration area dedicated to the rapidly growing sports nutrition industry. Here, visitors will be able to try AstaReal´s innovative effervescent containing natural astaxanthin at the sampling bar.

During the Integrative Healthcare Symposium held last week in New York, Professor Teodoro Bottiglieri – director of the Center of Metabolomics at Baylor Research Institute in Texas – gave an interesting speech on the Role of Folate and S-adenosylmethionine in Neuropsychiatric Disorders, which drew the attention of a large public.

The event was actively attended by participants, thus confirming the great concern in this specific topic, and was an opportunity to reiterate the extraordinary features of Quatrefolic®, the glucosamine salt of (6S)-5-methyltetrahydrofolate, structurally analogous to the reduced and active form of folate, able to support and regulate the methylation cycle ensuring a higher folate uptake.

The speech has provided a broad perspective on the role, efficacy and safety of Adonat^® (S-adenosylmethionine –SAMe) in the treatment of mood impairment, neuropsychiatric disorders and co-morbid medical conditions.

Prof. Bottiglieri, as a leading expert of One Carbon Metabolism, described symptoms and causes of folate deficiency and, supported by the results of several clinical trials, explained the essential role of B vitamins and methyl-group donors to reduce specific disease states and especially neurodegenerative disorders.